Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions

For an efficacious vaccine immunogen, influenza hemagglutinin (HA) needs to maintain a stable quaternary structure, which is contrary to the inherently dynamic and metastable nature of class I fusion proteins. In this study, we stabilized HA with three substitutions within its pH-sensitive regions w...

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Detalles Bibliográficos
Autores principales: Milder, Fin J., Jongeneelen, Mandy, Ritschel, Tina, Bouchier, Pascale, Bisschop, Ilona J. M., de Man, Martijn, Veldman, Daniel, Le, Lam, Kaufmann, Baerbel, Bakkers, Mark J. G., Juraszek, Jarek, Brandenburg, Boerries, Langedijk, Johannes P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833195/
https://www.ncbi.nlm.nih.gov/pubmed/35131851
http://dx.doi.org/10.1073/pnas.2115379119

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