IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines

The tumor microenvironment (TME) provides potential targets for cancer therapy. However, how signals originating in cancer cells affect tumor-directed immunity is largely unknown. Deletions in the CHUK locus, coding for IκB kinase α (IKKα), correlate with reduced lung adenocarcinoma (ADC) patient su...

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Detalles Bibliográficos
Autores principales: Song, Na-Young, Li, Xin, Ma, Buyong, Willette-Brown, Jami, Zhu, Feng, Jiang, Chengfei, Su, Ling, Shetty, Jyoti, Zhao, Yongmei, Shi, Gongping, Banerjee, Sayantan, Wu, Xiaolin, Tran, Bao, Nussinov, Ruth, Karin, Michael, Hu, Yinling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833198/
https://www.ncbi.nlm.nih.gov/pubmed/35121655
http://dx.doi.org/10.1073/pnas.2120956119

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