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DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor

Nature evolves molecular interaction networks through persistent perturbation and selection, in stark contrast to drug discovery, which evaluates candidates one at a time by screening. Here, nature’s highly parallel ligand-target search paradigm is recapitulated in a screen of a DNA-encoded library...

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Detalles Bibliográficos
Autores principales:	Benhamou, Raphael I., Suresh, Blessy M., Tong, Yuquan, Cochrane, Wesley G., Cavett, Valerie, Vezina-Dawod, Simon, Abegg, Daniel, Childs-Disney, Jessica L., Adibekian, Alexander, Paegel, Brian M., Disney, Matthew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833215/ https://www.ncbi.nlm.nih.gov/pubmed/35110406 http://dx.doi.org/10.1073/pnas.2114971119

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