Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

The α-synuclein protein can adopt several different conformations that cause neurodegeneration. Different α-synuclein conformers cause at least three distinct α-synucleinopathies: multiple system atrophy (MSA), dementia with Lewy bodies (DLB), and Parkinson’s disease (PD). In earlier studies, we tra...

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Detalles Bibliográficos
Autores principales: Ayers, Jacob I., Lee, Joanne, Monteiro, Octovia, Woerman, Amanda L., Lazar, Ann A., Condello, Carlo, Paras, Nick A., Prusiner, Stanley B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833220/
https://www.ncbi.nlm.nih.gov/pubmed/35115402
http://dx.doi.org/10.1073/pnas.2113489119

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