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Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis
An association between age-related hearing loss (ARHL) and Alzheimer's Disease (AD) has been widely reported. However, the nature of this relationship remains poorly understood. Quantification of hearing loss as it relates to AD is imperative for the creation of reliable, hearing-related biomar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833234/ https://www.ncbi.nlm.nih.gov/pubmed/35153910 http://dx.doi.org/10.3389/fpsyg.2021.788045 |
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author | Kwok, Susanna S. Nguyen, Xuan-Mai T. Wu, Diana D. Mudar, Raksha A. Llano, Daniel A. |
author_facet | Kwok, Susanna S. Nguyen, Xuan-Mai T. Wu, Diana D. Mudar, Raksha A. Llano, Daniel A. |
author_sort | Kwok, Susanna S. |
collection | PubMed |
description | An association between age-related hearing loss (ARHL) and Alzheimer's Disease (AD) has been widely reported. However, the nature of this relationship remains poorly understood. Quantification of hearing loss as it relates to AD is imperative for the creation of reliable, hearing-related biomarkers for earlier diagnosis and development of ARHL treatments that may slow the progression of AD. Previous studies that have measured the association between peripheral hearing function and AD have yielded mixed results. Most of these studies have been small and underpowered to reveal an association. Therefore, in the current report, we sought to estimate the degree to which AD patients have impaired hearing by performing a meta-analysis to increase statistical power. We reviewed 248 published studies that quantified peripheral hearing function using pure-tone audiometry for subjects with AD. Six studies, with a combined total of 171 subjects with AD compared to 222 age-matched controls, met inclusion criteria. We found a statistically significant increase in hearing threshold as measured by pure tone audiometry for subjects with AD compared to controls. For a three-frequency pure tone average calculated for air conduction thresholds at 500–1,000–2,000 Hz (0.5–2 kHz PTA), an increase of 2.3 decibel hearing level (dB HL) was found in subjects with AD compared to controls (p = 0.001). Likewise, for a four-frequency pure tone average calculated at 500–1,000–2,000–4,000 (0.5–4 kHz PTA), an increase of 4.5 dB HL was measured (p = 0.002), and this increase was significantly greater than that seen for 0.5–2 kHz PTA. There was no difference in the average age of the control and AD subjects. These data confirm the presence of poorer hearing ability in AD subjects, provided a quantitative estimate of the magnitude of hearing loss, and suggest that the magnitude of the effect is greater at higher sound frequencies. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42021288280. |
format | Online Article Text |
id | pubmed-8833234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88332342022-02-12 Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis Kwok, Susanna S. Nguyen, Xuan-Mai T. Wu, Diana D. Mudar, Raksha A. Llano, Daniel A. Front Psychol Psychology An association between age-related hearing loss (ARHL) and Alzheimer's Disease (AD) has been widely reported. However, the nature of this relationship remains poorly understood. Quantification of hearing loss as it relates to AD is imperative for the creation of reliable, hearing-related biomarkers for earlier diagnosis and development of ARHL treatments that may slow the progression of AD. Previous studies that have measured the association between peripheral hearing function and AD have yielded mixed results. Most of these studies have been small and underpowered to reveal an association. Therefore, in the current report, we sought to estimate the degree to which AD patients have impaired hearing by performing a meta-analysis to increase statistical power. We reviewed 248 published studies that quantified peripheral hearing function using pure-tone audiometry for subjects with AD. Six studies, with a combined total of 171 subjects with AD compared to 222 age-matched controls, met inclusion criteria. We found a statistically significant increase in hearing threshold as measured by pure tone audiometry for subjects with AD compared to controls. For a three-frequency pure tone average calculated for air conduction thresholds at 500–1,000–2,000 Hz (0.5–2 kHz PTA), an increase of 2.3 decibel hearing level (dB HL) was found in subjects with AD compared to controls (p = 0.001). Likewise, for a four-frequency pure tone average calculated at 500–1,000–2,000–4,000 (0.5–4 kHz PTA), an increase of 4.5 dB HL was measured (p = 0.002), and this increase was significantly greater than that seen for 0.5–2 kHz PTA. There was no difference in the average age of the control and AD subjects. These data confirm the presence of poorer hearing ability in AD subjects, provided a quantitative estimate of the magnitude of hearing loss, and suggest that the magnitude of the effect is greater at higher sound frequencies. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42021288280. Frontiers Media S.A. 2022-01-21 /pmc/articles/PMC8833234/ /pubmed/35153910 http://dx.doi.org/10.3389/fpsyg.2021.788045 Text en Copyright © 2022 Kwok, Nguyen, Wu, Mudar and Llano. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Kwok, Susanna S. Nguyen, Xuan-Mai T. Wu, Diana D. Mudar, Raksha A. Llano, Daniel A. Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis |
title | Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis |
title_full | Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis |
title_fullStr | Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis |
title_full_unstemmed | Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis |
title_short | Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis |
title_sort | pure tone audiometry and hearing loss in alzheimer's disease: a meta-analysis |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833234/ https://www.ncbi.nlm.nih.gov/pubmed/35153910 http://dx.doi.org/10.3389/fpsyg.2021.788045 |
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