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Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication

Acute intoxication with 2,4-D dimethylamine is rare, often fatal and can cause signs and symptoms in different organ systems. This case report describes the effectiveness of alkaline diuresis as a life-saving treatment for chlorophenoxy intoxication, especially in healthcare facilities without acces...

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Autores principales: Badu, Apolonia Berenika, Cempakadewi, Ade Ajeng, Budihardja, Brigitta Marcia, Ake, Anselmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833296/
https://www.ncbi.nlm.nih.gov/pubmed/35169579
http://dx.doi.org/10.12890/2022_003126
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author Badu, Apolonia Berenika
Cempakadewi, Ade Ajeng
Budihardja, Brigitta Marcia
Ake, Anselmus
author_facet Badu, Apolonia Berenika
Cempakadewi, Ade Ajeng
Budihardja, Brigitta Marcia
Ake, Anselmus
author_sort Badu, Apolonia Berenika
collection PubMed
description Acute intoxication with 2,4-D dimethylamine is rare, often fatal and can cause signs and symptoms in different organ systems. This case report describes the effectiveness of alkaline diuresis as a life-saving treatment for chlorophenoxy intoxication, especially in healthcare facilities without access to haemodialysis. A patient had attempted suicide by ingesting 2,4-D dimethylamine, with toxic effects on the central and peripheral nervous systems, and the gastrointestinal and respiratory systems. However, she significantly improved after alkaline diuresis, accompanied by resuscitation, decontamination of the gastrointestinal system, and supportive therapies. LEARNING POINTS: With no known of antidote, 2,4-D dimethylamine intoxication can be fatal if not treated promptly. Alkaline diuresis can be a life-saving treatment, especially in rural area with no access to haemodialysis. Treatment with alkaline diuresis can give a good result in patients who present with severe intoxication.
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spelling pubmed-88332962022-02-14 Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication Badu, Apolonia Berenika Cempakadewi, Ade Ajeng Budihardja, Brigitta Marcia Ake, Anselmus Eur J Case Rep Intern Med Articles Acute intoxication with 2,4-D dimethylamine is rare, often fatal and can cause signs and symptoms in different organ systems. This case report describes the effectiveness of alkaline diuresis as a life-saving treatment for chlorophenoxy intoxication, especially in healthcare facilities without access to haemodialysis. A patient had attempted suicide by ingesting 2,4-D dimethylamine, with toxic effects on the central and peripheral nervous systems, and the gastrointestinal and respiratory systems. However, she significantly improved after alkaline diuresis, accompanied by resuscitation, decontamination of the gastrointestinal system, and supportive therapies. LEARNING POINTS: With no known of antidote, 2,4-D dimethylamine intoxication can be fatal if not treated promptly. Alkaline diuresis can be a life-saving treatment, especially in rural area with no access to haemodialysis. Treatment with alkaline diuresis can give a good result in patients who present with severe intoxication. SMC Media Srl 2022-01-19 /pmc/articles/PMC8833296/ /pubmed/35169579 http://dx.doi.org/10.12890/2022_003126 Text en © EFIM 2022 This article is licensed under a Commons Attribution Non-Commercial 4.0 License
spellingShingle Articles
Badu, Apolonia Berenika
Cempakadewi, Ade Ajeng
Budihardja, Brigitta Marcia
Ake, Anselmus
Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication
title Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication
title_full Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication
title_fullStr Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication
title_full_unstemmed Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication
title_short Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication
title_sort alkaline diuresis as treatment for 2,4-d dimethylamine herbicide intoxication
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833296/
https://www.ncbi.nlm.nih.gov/pubmed/35169579
http://dx.doi.org/10.12890/2022_003126
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