Parvovirus Infection Triggering Still’s Disease

We present the case of a 59-year-old man with acute B19 parvovirus infection who developed a systemic inflammatory reaction similar to adult-onset Still’s disease (AOSD). We discuss the clinical challenge due to overlapping symptoms to distinguish between a primary B19 viral infection and the autoimmune disease it can trigger. LEARNING POINTS: Distinguishing between primary B19 parvovirus infection and autoimmune diseases can be difficult in view of the significant symptom overlap. In our patient, recurrence of symptoms during follow-up and response to treatment were in favour of adult-onset Still’s disease triggered by B19 parvovirus.