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Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis

Dysphagia has a broad aetiology and so it is essential to identify the precise cause. Cervical cancer metastasis is distinctive in that it usually involves local lymph node invasion; however, approximately 1% of cases have mediastinal involvement, which can cause severe compressive symptoms in rare...

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Autores principales: Singh, Vinit, Gor, Dhairya, Azad, Sarah, Ricca, Anthony, Xu, Yiqing, Meghal, Trishala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833304/
https://www.ncbi.nlm.nih.gov/pubmed/35169582
http://dx.doi.org/10.12890/2022_003136
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author Singh, Vinit
Gor, Dhairya
Azad, Sarah
Ricca, Anthony
Xu, Yiqing
Meghal, Trishala
author_facet Singh, Vinit
Gor, Dhairya
Azad, Sarah
Ricca, Anthony
Xu, Yiqing
Meghal, Trishala
author_sort Singh, Vinit
collection PubMed
description Dysphagia has a broad aetiology and so it is essential to identify the precise cause. Cervical cancer metastasis is distinctive in that it usually involves local lymph node invasion; however, approximately 1% of cases have mediastinal involvement, which can cause severe compressive symptoms in rare situations. To highlight an uncommon severe manifestation of cervical cancer relapse, we describe a case of dysphagia in a woman with a history of cervical cancer. After a thorough investigation that included endoscopy, endoscopy with ultrasound, an oesophagogram and fine needle aspiration, we eventually reached the diagnosis of mediastinal metastatic cervical cancer. Following interventions, the patient’s condition gradually improved, both clinically and radiographically. LEARNING POINTS: Mediastinal lymph node enlargement causing dysphagia can be a presenting sign of a metastatic lesion from treated cervical cancer. A PEG tube is helpful in relieving dysphagia caused by metastatic mediastinal lymph node enlargement and as bridge for nutrition during chemotherapy. The VEGF inhibitor bevacizumab can be used in advanced metastatic cervical cancer. Check-point inhibitors like pembrolizumab can be used in metastatic cervical cancer.
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spelling pubmed-88333042022-02-14 Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis Singh, Vinit Gor, Dhairya Azad, Sarah Ricca, Anthony Xu, Yiqing Meghal, Trishala Eur J Case Rep Intern Med Articles Dysphagia has a broad aetiology and so it is essential to identify the precise cause. Cervical cancer metastasis is distinctive in that it usually involves local lymph node invasion; however, approximately 1% of cases have mediastinal involvement, which can cause severe compressive symptoms in rare situations. To highlight an uncommon severe manifestation of cervical cancer relapse, we describe a case of dysphagia in a woman with a history of cervical cancer. After a thorough investigation that included endoscopy, endoscopy with ultrasound, an oesophagogram and fine needle aspiration, we eventually reached the diagnosis of mediastinal metastatic cervical cancer. Following interventions, the patient’s condition gradually improved, both clinically and radiographically. LEARNING POINTS: Mediastinal lymph node enlargement causing dysphagia can be a presenting sign of a metastatic lesion from treated cervical cancer. A PEG tube is helpful in relieving dysphagia caused by metastatic mediastinal lymph node enlargement and as bridge for nutrition during chemotherapy. The VEGF inhibitor bevacizumab can be used in advanced metastatic cervical cancer. Check-point inhibitors like pembrolizumab can be used in metastatic cervical cancer. SMC Media Srl 2022-01-24 /pmc/articles/PMC8833304/ /pubmed/35169582 http://dx.doi.org/10.12890/2022_003136 Text en © EFIM 2022 This article is licensed under a Commons Attribution Non-Commercial 4.0 License
spellingShingle Articles
Singh, Vinit
Gor, Dhairya
Azad, Sarah
Ricca, Anthony
Xu, Yiqing
Meghal, Trishala
Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis
title Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis
title_full Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis
title_fullStr Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis
title_full_unstemmed Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis
title_short Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis
title_sort dysphagia as a rare presentation of cervical cancer with mediastinal metastasis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833304/
https://www.ncbi.nlm.nih.gov/pubmed/35169582
http://dx.doi.org/10.12890/2022_003136
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