The long and the short of Huntington’s disease: how the sphingolipid profile is shifted in the caudate of advanced clinical cases

Huntington’s disease is a devastating neurodegenerative disorder that onsets in late adulthood as progressive and terminal cognitive, psychiatric and motor deficits. The disease is genetic, triggered by a CAG repeat (polyQ) expansion mutation in the Huntingtin gene and resultant huntingtin protein....

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Detalles Bibliográficos
Autores principales: Phillips, Gabrielle R., Saville, Jennifer T., Hancock, Sarah E., Brown, Simon H. J., Jenner, Andrew M., McLean, Catriona, Fuller, Maria, Newell, Kelly A., Mitchell, Todd W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833324/
https://www.ncbi.nlm.nih.gov/pubmed/35169703
http://dx.doi.org/10.1093/braincomms/fcab303

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