Do We Need to Delineate the Humeral Head in Breast Cancer Patients?

SIMPLE SUMMARY: Humeral heads can be unintentionally exposed during breast radiotherapy, particularly when regional lymph nodes are targeted. The aim of this study was to analyze late adverse events involving the humeral head occurring after adjuvant locoregional breast radiotherapy. We included 159 breast cancer patients locoregionally irradiated in an adjuvant setting with helical tomotherapy. After a median delay of 48 months, 10 patients (6.06% (3.20–10.92%) of breasts treated) presented clinical events such as localized bone pain, shoulder functional limitation and humeral head fracture. The average mean and maximum doses to humeral heads were 9.18 Gy and 24.41 Gy, respectively, and were not statistically associated with humeral head adverse events. We found that clinical adverse events involving the humeral head after adjuvant helical tomotherapy for breast cancer were rare, and the radiation exposure was low. No correlation was found between dosimetric parameters and late toxicity. ABSTRACT: Humeral heads can be unintentionally exposed during breast radiotherapy, particularly when regional lymph nodes are targeted. Moreover, rotational intensity-modulated radiation therapy techniques, such as helical tomotherapy (HT), increase the low-dose bath, the consequences of which are subject to debate. The aim of this study was to analyze late adverse events involving humeral heads occurring after adjuvant locoregional breast radiotherapy with HT. This single-center retrospective study included 159 breast cancer patients locoregionally irradiated, including the regional lymph nodes, in an adjuvant setting with HT at Institut Curie (Paris, France), between January 2010 and 2016. After a median delay of 48 months, six patients (3.8%) developed localized bone pain, three (1.9%) developed a shoulder functional limitation and one (0.6%) developed a traumatic humeral head fracture. The average mean and maximum doses to humeral heads were 9.18 Gy and 24.41 Gy, respectively, and were not statistically associated with humeral head adverse events. Adverse events were statistically more frequent after mastectomy than after breast-conserving surgery. Berg’s level 1 and 2/3 irradiation, and right-sided radiotherapy were associated with an increased maximum dose. In summary, clinical adverse events were rare, and radiation exposure to humeral heads was low. No correlation was found between dosimetric parameters and late toxicity.