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Loss of Neuropilin-2 in Murine Mesenchymal-like Colon Cancer Organoids Causes Mesenchymal-to-Epithelial Transition and an Acquired Dependency on Insulin-Receptor Signaling and Autophagy

SIMPLE SUMMARY: Many cancer types are reported to have high lymphangiogenic receptor Neuropilin-2 (Nrp2) expression, including colorectal cancer (CRC). Nrp2 is shown to be associated with tumor progression in vivo and poor prognosis in CRC patients. Although the role of Nrp2 is well established in l...

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Detalles Bibliográficos
Autores principales:	Poghosyan, Susanna, Frenkel, Nicola, Lentzas, Aristeidis, Laoukili, Jamila, Rinkes, Inne Borel, Kranenburg, Onno, Hagendoorn, Jeroen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833430/ https://www.ncbi.nlm.nih.gov/pubmed/35158941 http://dx.doi.org/10.3390/cancers14030671

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