Dual Inhibition of Myc Transcription and PI3K Activity Effectively Targets Colorectal Cancer Stem Cells

SIMPLE SUMMARY: Compelling evidence has shown that cancer stem cells (CSCs) are responsible for high resistance to conventional anti-cancer therapies. Here, we demonstrate that the tumor microenvironment protects CR-CSCs from EGFR/HER2, BRAF and PI3K targeting, promoting CD44v6 and Myc expression. A...

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Detalles Bibliográficos
Autores principales: Gaggianesi, Miriam, Mangiapane, Laura Rosa, Modica, Chiara, Pantina, Vincenzo Davide, Porcelli, Gaetana, Di Franco, Simone, Lo Iacono, Melania, D’Accardo, Caterina, Verona, Francesco, Pillitteri, Irene, Turdo, Alice, Veschi, Veronica, Brancato, Ornella Roberta, Muratore, Giampaolo, Pistone, Giuseppe, Bongiorno, Maria Rita, Todaro, Matilde, De Maria, Ruggero, Stassi, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833549/
https://www.ncbi.nlm.nih.gov/pubmed/35158939
http://dx.doi.org/10.3390/cancers14030673

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