Radiomics Features of the Spleen as Surrogates for CT-Based Lymphoma Diagnosis and Subtype Differentiation

SIMPLE SUMMARY: In malignant lymphoma an early and accurate diagnosis is essential for therapy initiation and patient outcome. Within the diagnostic process, imaging plays a crucial role in disease staging. However, an invasive biopsy is required for subtype classification. Involvement of the spleen, a major lymphoid organ, is frequent in malignant lymphoma; this may be reactive or due to infiltration by malignant cells. Using radiomics features of the spleen in a machine learning approach, we investigated the possibility of distinguishing malignant lymphoma patients from other cancer patients and to classify lymphoma subtypes in the case of disease presence. Recent studies have proven the value of radiomics analysis in differentiating lymphoma from non-lymphoma groups on involved sites. Supported by machine learning, imaging could gain importance as a noninvasive diagnostic tool for future lymphoma classification, offering more precise radiological information for an interdisciplinary approach regarding treatment planning. ABSTRACT: The spleen is often involved in malignant lymphoma, which manifests on CT as either splenomegaly or focal, hypodense lymphoma lesions. This study aimed to investigate the diagnostic value of radiomics features of the spleen in classifying malignant lymphoma against non-lymphoma as well as the determination of malignant lymphoma subtypes in the case of disease presence—in particular Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), mantle-cell lymphoma (MCL), and follicular lymphoma (FL). Spleen segmentations of 326 patients (139 female, median age 54.1 +/− 18.7 years) were generated and 1317 radiomics features per patient were extracted. For subtype classification, we created four different binary differentiation tasks and addressed them with a Random Forest classifier using 10-fold cross-validation. To detect the most relevant features, permutation importance was analyzed. Classifier results using all features were: malignant lymphoma vs. non-lymphoma AUC = 0.86 (p < 0.01); HL vs. NHL AUC = 0.75 (p < 0.01); DLBCL vs. other NHL AUC = 0.65 (p < 0.01); MCL vs. FL AUC = 0.67 (p < 0.01). Classifying malignant lymphoma vs. non-lymphoma was also possible using only shape features AUC = 0.77 (p < 0.01), with the most important feature being sphericity. Based on only shape features, a significant AUC could be achieved for all tasks, however, best results were achieved combining shape and textural features. This study demonstrates the value of splenic imaging and radiomic analysis in the diagnostic process in malignant lymphoma detection and subtype classification.