Early-Stage Lung Adenocarcinoma MDM2 Genomic Amplification Predicts Clinical Outcome and Response to Targeted Therapy

SIMPLE SUMMARY: Invasive subtypes of lung adenocarcinoma (LUAD) show MDM2 amplification that is associated with poor survival. Mouse double minute 2 (MDM2) is frequently amplified in lung adenocarcinoma (LUAD) and is a negative regulator of p53, which binds to p53 and regulates its activity and stab...

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Detalles Bibliográficos
Autores principales: Sinha, Abhilasha, Zou, Yong, Patel, Ayushi S., Yoo, Seungyeul, Jiang, Feng, Sato, Takashi, Kong, Ranran, Watanabe, Hideo, Zhu, Jun, Massion, Pierre P., Borczuk, Alain C., Powell, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833784/
https://www.ncbi.nlm.nih.gov/pubmed/35158979
http://dx.doi.org/10.3390/cancers14030708

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