Orchidaceae-Derived Anticancer Agents: A Review

SIMPLE SUMMARY: Orchids are commonly used in folk medicine for the treatment of infections and tumors but little is known about the actual chemical composition of these plants and their anticancer properties. In this paper, the most recent literature on orchid-derived bioactive substances with anticancer properties is reviewed. According to the published data, numerous species of orchids contain potential antitumor chemicals. Still, a relatively insignificant number of species of orchids have been tested for their bioactive properties and most of those studies were on Asian taxa. Broader research, ’including American and African species, as well as the correct identification of samples, is essential for evaluating the usefulness of orchids as a plant family with huge anticancer potential. ABSTRACT: Species of orchids, which belong to the largest family of flowering plants, are commonly used in folk medicine for the treatment of infections and tumors. However, little is known about the actual chemical composition of these plants and their anticancer properties. In this paper, the most recent literature on orchid-derived bioactive substances with anticancer properties is reviewed. For the assessment, previous papers on the anticancer activity of Orchidaceae published since 2015 were considered. The papers were found by exploring electronic databases. According to the available data, many species of orchids contain potential antitumor chemicals. The bioactive substances in a relatively insignificant number of orchids are identified, and most studies are on Asian taxa. Broader research on American and African species and the correct identification of samples included in the experiments are essential for evaluating the usefulness of orchids as a plant family with vast anticancer potential.