Cargando…

The Anti-Acne Potential and Chemical Composition of Two Cultivated Cotoneaster Species

In light of current knowledge on the role of reactive oxygen species and other oxidants in skin diseases, it is clear that oxidative stress facilitates inflammation and is an important factor involved in skin diseases, i.e., acne. Taking into consideration the fact that some Cotoneaster plants are v...

Descripción completa

Detalles Bibliográficos
Autores principales: Krzemińska, Barbara, Dybowski, Michał P., Klimek, Katarzyna, Typek, Rafał, Miazga-Karska, Małgorzata, Dos Santos Szewczyk, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834067/
https://www.ncbi.nlm.nih.gov/pubmed/35159177
http://dx.doi.org/10.3390/cells11030367
_version_ 1784649090827550720
author Krzemińska, Barbara
Dybowski, Michał P.
Klimek, Katarzyna
Typek, Rafał
Miazga-Karska, Małgorzata
Dos Santos Szewczyk, Katarzyna
author_facet Krzemińska, Barbara
Dybowski, Michał P.
Klimek, Katarzyna
Typek, Rafał
Miazga-Karska, Małgorzata
Dos Santos Szewczyk, Katarzyna
author_sort Krzemińska, Barbara
collection PubMed
description In light of current knowledge on the role of reactive oxygen species and other oxidants in skin diseases, it is clear that oxidative stress facilitates inflammation and is an important factor involved in skin diseases, i.e., acne. Taking into consideration the fact that some Cotoneaster plants are valuable curatives in skin diseases in traditional Asian medicine, we assumed that thus far untested species C. hsingshangensis and C. hissaricus may be a source of substances used in skin diseases. The aim of this study was to evaluate the antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of their various extracts. LC-MS analysis revealed the presence of 47 compounds (flavonoids, phenolic acids, coumarins, sphingolipids, carbohydrates), while GC-MS procedure allowed for the identification of 42 constituents (sugar derivatives, phytosterols, fatty acids, and their esters). The diethyl ether fraction of C. hsingshangensis (CHs-2) exhibited great ability to scavenge free radicals and good capacity to inhibit cyclooxygenase-1, cyclooxygenase-2, lipoxygenase, and hyaluronidase. Moreover, it had the most promising power against microaerobic Gram-positive strains, and importantly, it was non-toxic toward normal skin fibroblasts. Taking into account the value of the calculated therapeutic index (>10), it is worth noting that CHs-2 can be subjected to in vivo study and constitutes a promising anti-acne agent.
format Online
Article
Text
id pubmed-8834067
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88340672022-02-12 The Anti-Acne Potential and Chemical Composition of Two Cultivated Cotoneaster Species Krzemińska, Barbara Dybowski, Michał P. Klimek, Katarzyna Typek, Rafał Miazga-Karska, Małgorzata Dos Santos Szewczyk, Katarzyna Cells Article In light of current knowledge on the role of reactive oxygen species and other oxidants in skin diseases, it is clear that oxidative stress facilitates inflammation and is an important factor involved in skin diseases, i.e., acne. Taking into consideration the fact that some Cotoneaster plants are valuable curatives in skin diseases in traditional Asian medicine, we assumed that thus far untested species C. hsingshangensis and C. hissaricus may be a source of substances used in skin diseases. The aim of this study was to evaluate the antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of their various extracts. LC-MS analysis revealed the presence of 47 compounds (flavonoids, phenolic acids, coumarins, sphingolipids, carbohydrates), while GC-MS procedure allowed for the identification of 42 constituents (sugar derivatives, phytosterols, fatty acids, and their esters). The diethyl ether fraction of C. hsingshangensis (CHs-2) exhibited great ability to scavenge free radicals and good capacity to inhibit cyclooxygenase-1, cyclooxygenase-2, lipoxygenase, and hyaluronidase. Moreover, it had the most promising power against microaerobic Gram-positive strains, and importantly, it was non-toxic toward normal skin fibroblasts. Taking into account the value of the calculated therapeutic index (>10), it is worth noting that CHs-2 can be subjected to in vivo study and constitutes a promising anti-acne agent. MDPI 2022-01-21 /pmc/articles/PMC8834067/ /pubmed/35159177 http://dx.doi.org/10.3390/cells11030367 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Krzemińska, Barbara
Dybowski, Michał P.
Klimek, Katarzyna
Typek, Rafał
Miazga-Karska, Małgorzata
Dos Santos Szewczyk, Katarzyna
The Anti-Acne Potential and Chemical Composition of Two Cultivated Cotoneaster Species
title The Anti-Acne Potential and Chemical Composition of Two Cultivated Cotoneaster Species
title_full The Anti-Acne Potential and Chemical Composition of Two Cultivated Cotoneaster Species
title_fullStr The Anti-Acne Potential and Chemical Composition of Two Cultivated Cotoneaster Species
title_full_unstemmed The Anti-Acne Potential and Chemical Composition of Two Cultivated Cotoneaster Species
title_short The Anti-Acne Potential and Chemical Composition of Two Cultivated Cotoneaster Species
title_sort anti-acne potential and chemical composition of two cultivated cotoneaster species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834067/
https://www.ncbi.nlm.nih.gov/pubmed/35159177
http://dx.doi.org/10.3390/cells11030367
work_keys_str_mv AT krzeminskabarbara theantiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT dybowskimichałp theantiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT klimekkatarzyna theantiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT typekrafał theantiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT miazgakarskamałgorzata theantiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT dossantosszewczykkatarzyna theantiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT krzeminskabarbara antiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT dybowskimichałp antiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT klimekkatarzyna antiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT typekrafał antiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT miazgakarskamałgorzata antiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies
AT dossantosszewczykkatarzyna antiacnepotentialandchemicalcompositionoftwocultivatedcotoneasterspecies