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LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner

Data gleaned recently shows that ghrelin, a stomach derived peptide, and liver-expressed-antimicrobial peptide 2 (LEAP-2) play opposite roles on food intake. However, the data available with LEAP-2 in relation to in vivo studies are still very scanty and some key questions regarding the interplay am...

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Autores principales: Lugilde, Javier, Casado, Sabela, Beiroa, Daniel, Cuñarro, Juan, Garcia-Lavandeira, Montserrat, Álvarez, Clara V., Nogueiras, Rubén, Diéguez, Carlos, Tovar, Sulay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834077/
https://www.ncbi.nlm.nih.gov/pubmed/35159134
http://dx.doi.org/10.3390/cells11030324
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author Lugilde, Javier
Casado, Sabela
Beiroa, Daniel
Cuñarro, Juan
Garcia-Lavandeira, Montserrat
Álvarez, Clara V.
Nogueiras, Rubén
Diéguez, Carlos
Tovar, Sulay
author_facet Lugilde, Javier
Casado, Sabela
Beiroa, Daniel
Cuñarro, Juan
Garcia-Lavandeira, Montserrat
Álvarez, Clara V.
Nogueiras, Rubén
Diéguez, Carlos
Tovar, Sulay
author_sort Lugilde, Javier
collection PubMed
description Data gleaned recently shows that ghrelin, a stomach derived peptide, and liver-expressed-antimicrobial peptide 2 (LEAP-2) play opposite roles on food intake. However, the data available with LEAP-2 in relation to in vivo studies are still very scanty and some key questions regarding the interplay among ghrelin and LEAP-2 remain to be answered. In this work, using rats and mice, we study fasting-induced food intake as well as testing the effect of diet exposure, e.g., standard diet and high fat diet, in terms of ghrelin-induced food intake. The anorexigenic effect of LEAP-2 on fasting induced food intake appears to be dependent on energy stores, being more evident in ob/ob than in wild type mice and also in animals exposed to high fat diet. On the other hand, LEAP-2 administration markedly inhibited ghrelin-induced food intake in lean, obese (ob/ob and DIO) mice, aged rats and GH-deficient dwarf rats. In contrast, the inhibitory effect on glucose levels can only be observed in some specific experimental models indicating that the mechanisms involved are likely to be quite different. Taken together from these data, LEAP-2 emerged as a potential candidate to be therapeutically useful in obesity.
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spelling pubmed-88340772022-02-12 LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner Lugilde, Javier Casado, Sabela Beiroa, Daniel Cuñarro, Juan Garcia-Lavandeira, Montserrat Álvarez, Clara V. Nogueiras, Rubén Diéguez, Carlos Tovar, Sulay Cells Article Data gleaned recently shows that ghrelin, a stomach derived peptide, and liver-expressed-antimicrobial peptide 2 (LEAP-2) play opposite roles on food intake. However, the data available with LEAP-2 in relation to in vivo studies are still very scanty and some key questions regarding the interplay among ghrelin and LEAP-2 remain to be answered. In this work, using rats and mice, we study fasting-induced food intake as well as testing the effect of diet exposure, e.g., standard diet and high fat diet, in terms of ghrelin-induced food intake. The anorexigenic effect of LEAP-2 on fasting induced food intake appears to be dependent on energy stores, being more evident in ob/ob than in wild type mice and also in animals exposed to high fat diet. On the other hand, LEAP-2 administration markedly inhibited ghrelin-induced food intake in lean, obese (ob/ob and DIO) mice, aged rats and GH-deficient dwarf rats. In contrast, the inhibitory effect on glucose levels can only be observed in some specific experimental models indicating that the mechanisms involved are likely to be quite different. Taken together from these data, LEAP-2 emerged as a potential candidate to be therapeutically useful in obesity. MDPI 2022-01-19 /pmc/articles/PMC8834077/ /pubmed/35159134 http://dx.doi.org/10.3390/cells11030324 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lugilde, Javier
Casado, Sabela
Beiroa, Daniel
Cuñarro, Juan
Garcia-Lavandeira, Montserrat
Álvarez, Clara V.
Nogueiras, Rubén
Diéguez, Carlos
Tovar, Sulay
LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner
title LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner
title_full LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner
title_fullStr LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner
title_full_unstemmed LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner
title_short LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner
title_sort leap-2 counteracts ghrelin-induced food intake in a nutrient, growth hormone and age independent manner
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834077/
https://www.ncbi.nlm.nih.gov/pubmed/35159134
http://dx.doi.org/10.3390/cells11030324
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