Cargando…

LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner

Data gleaned recently shows that ghrelin, a stomach derived peptide, and liver-expressed-antimicrobial peptide 2 (LEAP-2) play opposite roles on food intake. However, the data available with LEAP-2 in relation to in vivo studies are still very scanty and some key questions regarding the interplay am...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lugilde, Javier, Casado, Sabela, Beiroa, Daniel, Cuñarro, Juan, Garcia-Lavandeira, Montserrat, Álvarez, Clara V., Nogueiras, Rubén, Diéguez, Carlos, Tovar, Sulay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834077/ https://www.ncbi.nlm.nih.gov/pubmed/35159134 http://dx.doi.org/10.3390/cells11030324

Ejemplares similares

Hypothalamic Mitochondrial Dysfunction as a Target in Obesity and Metabolic Disease
por: Cunarro, Juan, et al.
Publicado: (2018)

Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender
por: Sanchez-Rebordelo, Estrella, et al.
Publicado: (2018)

Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy
por: Garcés, Maria Fernanda, et al.
Publicado: (2022)

OR12-04 LEAP2 Deletion Does Not Counteract The Effects Of Ghrelin Deletion During Insulin-Induced-Hypoglycemia
por: Shankar, Kripa, et al.
Publicado: (2023)

Levels of the Novel Endogenous Antagonist of Ghrelin Receptor, Liver-Enriched Antimicrobial Peptide-2, in Patients with Rheumatoid Arthritis
por: Francisco, Vera, et al.
Publicado: (2020)

The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa
por: Tezenas du Montcel, Chloé, et al.
Publicado: (2023)

Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin
por: Martins, Luís, et al.
Publicado: (2012)

Effect of Oral Glucose Administration on Rebound Growth Hormone Release in Normal and Obese Women: The Role of Adiposity, Insulin Sensitivity and Ghrelin
por: Pena-Bello, Lara, et al.
Publicado: (2015)

The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system
por: Lodeiro, Maria, et al.
Publicado: (2011)

LEAP-2: An Emerging Endogenous Ghrelin Receptor Antagonist in the Pathophysiology of Obesity
por: Lu, Xuehan, et al.
Publicado: (2021)

“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”
por: Gupta, Deepali, et al.
Publicado: (2020)

Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2
por: Holm, Stephanie, et al.
Publicado: (2022)

Glucagon Control on Food Intake and Energy Balance
por: Al-Massadi, Omar, et al.
Publicado: (2019)

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin
por: Velásquez, Douglas A., et al.
Publicado: (2011)

LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue
por: Shankar, Kripa, et al.
Publicado: (2021)

Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner
por: Quiñones, Mar, et al.
Publicado: (2021)

Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome
por: Rial-Pensado, Eva, et al.
Publicado: (2022)

Heterozygous Deficiency of Endoglin Decreases Insulin and Hepatic Triglyceride Levels during High Fat Diet
por: Beiroa, Daniel, et al.
Publicado: (2013)

Nutritional Status, Selected Nutrients Intake and Their Relationship with the Concentration of Ghrelin and Adiponectin in Patients with Diabetic Nephropathy
por: Boniecka, Iwona, et al.
Publicado: (2021)

LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study
por: Vergani, Edoardo, et al.
Publicado: (2021)

The role of dysregulated ghrelin/LEAP-2 balance in eating disorder: a translational study in anorexia nervosa.
por: Tezenas du Montcel, C.
Publicado: (2023)

The role of dysregulated ghrelin/LEAP-2 balance in eating disorder: a translational study in anorexia nervosa
por: Tezenas du Montcel, C., et al.
Publicado: (2023)

mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol
por: González-García, Ismael, et al.
Publicado: (2018)

Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids
por: Li, Jiaxi, et al.
Publicado: (2022)

MECHANISMS IN ENDOCRINOLOGY: The gut–brain axis: regulating energy balance independent of food intake
por: Nogueiras, Ruben
Publicado: (2021)

Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP
por: Imbernon, Monica, et al.
Publicado: (2014)

Ghrelin
por: Müller, T.D., et al.
Publicado: (2015)

Ghrelin increases intake of rewarding food in rodents
por: Egecioglu, Emil, et al.
Publicado: (2010)

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
por: Vazquez, M. J., et al.
Publicado: (2018)

PMON253 The Ghrelin/Leap-2 ratio might be associated with physiologic changes in maternal weight during different stages of pregnancy
por: Buell-Acosta, Julieth Daniela, et al.
Publicado: (2022)

Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice
por: Pazos, Patricia, et al.
Publicado: (2015)

J‐LEAPS peptide and LEAPS dendritic cell vaccines
por: Rosenthal, Ken S., et al.
Publicado: (2012)

Preprandial ghrelin is not affected by macronutrient intake, energy intake or energy expenditure
por: Paul, David R, et al.
Publicado: (2005)

Involvement of POMC neurons in LEAP2 regulation of food intake and body weight
por: Chu, Guangpin, et al.
Publicado: (2022)

LEAP LEAR
Publicado: (1996)

Leaps in genetics
por: Damle, S. G.
Publicado: (2010)

Quantum leaps
por: Bernstein, Jeremy
Publicado: (2009)

Counteractive Effects of Choline Geranate (CAGE) ILs and Ethanol on Insulin’s Stability—A Leap Forward towards Oral Insulin Formulation
por: Palanisamy, Kandhan, et al.
Publicado: (2022)

Effect of Pioglitazone on Energy Intake and Ghrelin in Diabetic Patients
por: Martin, Corby K., et al.
Publicado: (2010)

Ghrelin, food intake, and botanical extracts: A Review
por: Rezaie, Peyman, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vngp9oh26ej4cqkhfbfh702d8c