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Mucosal Mast Cells as Key Effector Cells in Food Allergies

Mucosal mast cells (MMCs) localized in the intestinal mucosa play a key role in the development of IgE-mediated food allergies. Recent advances have revealed that MMCs are a distinctly different population from connective tissue mast cells localized in skin and other connective tissues. MMCs are ind...

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Autores principales: Nakano, Nobuhiro, Kitaura, Jiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834119/
https://www.ncbi.nlm.nih.gov/pubmed/35159139
http://dx.doi.org/10.3390/cells11030329
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author Nakano, Nobuhiro
Kitaura, Jiro
author_facet Nakano, Nobuhiro
Kitaura, Jiro
author_sort Nakano, Nobuhiro
collection PubMed
description Mucosal mast cells (MMCs) localized in the intestinal mucosa play a key role in the development of IgE-mediated food allergies. Recent advances have revealed that MMCs are a distinctly different population from connective tissue mast cells localized in skin and other connective tissues. MMCs are inducible and transient cells that arise from bone marrow-derived mast cell progenitors, and their numbers increase rapidly during mucosal allergic inflammation. However, the mechanism of the dramatic expansion of MMCs and their cell functions are not well understood. Here, we review recent findings on the mechanisms of MMC differentiation and expansion, and we discuss the potential for the inducers of differentiation and expansion to serve as targets for food allergy therapy. In addition, we also discuss the mechanism by which oral immunotherapy, a promising treatment for food allergy patients, induces unresponsiveness to food allergens and the roles of MMCs in this process. Research focusing on MMCs should provide useful information for understanding the underlying mechanisms of food allergies in order to further advance the treatment of food allergies.
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spelling pubmed-88341192022-02-12 Mucosal Mast Cells as Key Effector Cells in Food Allergies Nakano, Nobuhiro Kitaura, Jiro Cells Review Mucosal mast cells (MMCs) localized in the intestinal mucosa play a key role in the development of IgE-mediated food allergies. Recent advances have revealed that MMCs are a distinctly different population from connective tissue mast cells localized in skin and other connective tissues. MMCs are inducible and transient cells that arise from bone marrow-derived mast cell progenitors, and their numbers increase rapidly during mucosal allergic inflammation. However, the mechanism of the dramatic expansion of MMCs and their cell functions are not well understood. Here, we review recent findings on the mechanisms of MMC differentiation and expansion, and we discuss the potential for the inducers of differentiation and expansion to serve as targets for food allergy therapy. In addition, we also discuss the mechanism by which oral immunotherapy, a promising treatment for food allergy patients, induces unresponsiveness to food allergens and the roles of MMCs in this process. Research focusing on MMCs should provide useful information for understanding the underlying mechanisms of food allergies in order to further advance the treatment of food allergies. MDPI 2022-01-19 /pmc/articles/PMC8834119/ /pubmed/35159139 http://dx.doi.org/10.3390/cells11030329 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nakano, Nobuhiro
Kitaura, Jiro
Mucosal Mast Cells as Key Effector Cells in Food Allergies
title Mucosal Mast Cells as Key Effector Cells in Food Allergies
title_full Mucosal Mast Cells as Key Effector Cells in Food Allergies
title_fullStr Mucosal Mast Cells as Key Effector Cells in Food Allergies
title_full_unstemmed Mucosal Mast Cells as Key Effector Cells in Food Allergies
title_short Mucosal Mast Cells as Key Effector Cells in Food Allergies
title_sort mucosal mast cells as key effector cells in food allergies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834119/
https://www.ncbi.nlm.nih.gov/pubmed/35159139
http://dx.doi.org/10.3390/cells11030329
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