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Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834148/ https://www.ncbi.nlm.nih.gov/pubmed/35159199 http://dx.doi.org/10.3390/cells11030390 |
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author | Machado-Santos, Ana R. Loureiro-Campos, Eduardo Patrício, Patrícia Araújo, Bruna Alves, Nuno Dinis Mateus-Pinheiro, António Correia, Joana Sofia Morais, Mónica Bessa, João M. Sousa, Nuno Rodrigues, Ana J. Oliveira, João Filipe Pinto, Luísa |
author_facet | Machado-Santos, Ana R. Loureiro-Campos, Eduardo Patrício, Patrícia Araújo, Bruna Alves, Nuno Dinis Mateus-Pinheiro, António Correia, Joana Sofia Morais, Mónica Bessa, João M. Sousa, Nuno Rodrigues, Ana J. Oliveira, João Filipe Pinto, Luísa |
author_sort | Machado-Santos, Ana R. |
collection | PubMed |
description | Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field. |
format | Online Article Text |
id | pubmed-8834148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88341482022-02-12 Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure Machado-Santos, Ana R. Loureiro-Campos, Eduardo Patrício, Patrícia Araújo, Bruna Alves, Nuno Dinis Mateus-Pinheiro, António Correia, Joana Sofia Morais, Mónica Bessa, João M. Sousa, Nuno Rodrigues, Ana J. Oliveira, João Filipe Pinto, Luísa Cells Article Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field. MDPI 2022-01-24 /pmc/articles/PMC8834148/ /pubmed/35159199 http://dx.doi.org/10.3390/cells11030390 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Machado-Santos, Ana R. Loureiro-Campos, Eduardo Patrício, Patrícia Araújo, Bruna Alves, Nuno Dinis Mateus-Pinheiro, António Correia, Joana Sofia Morais, Mónica Bessa, João M. Sousa, Nuno Rodrigues, Ana J. Oliveira, João Filipe Pinto, Luísa Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure |
title | Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure |
title_full | Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure |
title_fullStr | Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure |
title_full_unstemmed | Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure |
title_short | Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure |
title_sort | beyond new neurons in the adult hippocampus: imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834148/ https://www.ncbi.nlm.nih.gov/pubmed/35159199 http://dx.doi.org/10.3390/cells11030390 |
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