Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2

Besides BRCA1 and BRCA2, several other inheritable mutations have been identified that increase ovarian cancer risk. Surgical excision of the fallopian tubes and ovaries reduces ovarian cancer risk, but for some non-BRCA hereditary ovarian cancer mutations the benefit of this intervention is unclear...

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Autores principales: Samuel, David, Diaz-Barbe, Alexandra, Pinto, Andre, Schlumbrecht, Matthew, George, Sophia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834207/
https://www.ncbi.nlm.nih.gov/pubmed/35159349
http://dx.doi.org/10.3390/cells11030539
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author Samuel, David
Diaz-Barbe, Alexandra
Pinto, Andre
Schlumbrecht, Matthew
George, Sophia
author_facet Samuel, David
Diaz-Barbe, Alexandra
Pinto, Andre
Schlumbrecht, Matthew
George, Sophia
author_sort Samuel, David
collection PubMed
description Besides BRCA1 and BRCA2, several other inheritable mutations have been identified that increase ovarian cancer risk. Surgical excision of the fallopian tubes and ovaries reduces ovarian cancer risk, but for some non-BRCA hereditary ovarian cancer mutations the benefit of this intervention is unclear. The fallopian tubes of women with hereditary ovarian cancer mutations provide many insights into the early events of carcinogenesis and process of malignant transformation. Here we review cancer pathogenesis in hereditary cases of ovarian cancer, the occurrence of pre-invasive lesions and occult carcinoma in mutation carriers and their clinical management.
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spelling pubmed-88342072022-02-12 Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2 Samuel, David Diaz-Barbe, Alexandra Pinto, Andre Schlumbrecht, Matthew George, Sophia Cells Review Besides BRCA1 and BRCA2, several other inheritable mutations have been identified that increase ovarian cancer risk. Surgical excision of the fallopian tubes and ovaries reduces ovarian cancer risk, but for some non-BRCA hereditary ovarian cancer mutations the benefit of this intervention is unclear. The fallopian tubes of women with hereditary ovarian cancer mutations provide many insights into the early events of carcinogenesis and process of malignant transformation. Here we review cancer pathogenesis in hereditary cases of ovarian cancer, the occurrence of pre-invasive lesions and occult carcinoma in mutation carriers and their clinical management. MDPI 2022-02-04 /pmc/articles/PMC8834207/ /pubmed/35159349 http://dx.doi.org/10.3390/cells11030539 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Samuel, David
Diaz-Barbe, Alexandra
Pinto, Andre
Schlumbrecht, Matthew
George, Sophia
Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2
title Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2
title_full Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2
title_fullStr Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2
title_full_unstemmed Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2
title_short Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2
title_sort hereditary ovarian carcinoma: cancer pathogenesis looking beyond brca1 and brca2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834207/
https://www.ncbi.nlm.nih.gov/pubmed/35159349
http://dx.doi.org/10.3390/cells11030539
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AT schlumbrechtmatthew hereditaryovariancarcinomacancerpathogenesislookingbeyondbrca1andbrca2
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