Induction of Survival of Motor Neuron (SMN) Protein Deficiency in Spinal Astrocytes by Small Interfering RNA as an In Vitro Model of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a motor neuron disorder leading to progressive loss of ventral horn neurons resulting in muscle wasting. Here we investigate the contribution of spinal astrocytes to the pathogenesis of late-onset SMA forms using a mouse model. Furthermore, we generated SMA-like astr...

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Detalles Bibliográficos
Autores principales: Leo, Markus, Schmitt, Linda-Isabell, Fleischer, Michael, Steffen, Rebecca, Osswald, Cora, Kleinschnitz, Christoph, Hagenacker, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834238/
https://www.ncbi.nlm.nih.gov/pubmed/35159369
http://dx.doi.org/10.3390/cells11030558

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