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Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review

Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms indirectly. Numerous studies have been performed to dat...

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Detalles Bibliográficos
Autores principales: Ohnishi, Takashi, Iwasaki, Norimasa, Sudo, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834258/
https://www.ncbi.nlm.nih.gov/pubmed/35159202
http://dx.doi.org/10.3390/cells11030394
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author Ohnishi, Takashi
Iwasaki, Norimasa
Sudo, Hideki
author_facet Ohnishi, Takashi
Iwasaki, Norimasa
Sudo, Hideki
author_sort Ohnishi, Takashi
collection PubMed
description Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms indirectly. Numerous studies have been performed to date, and the major strategy for all treatments of IVDD is to prevent cell loss due to programmed or regulated cell death. Accumulating evidence suggests that several types of cell death other than apoptosis, including necroptosis, pyroptosis, and ferroptosis, are also involved in IVDD. In this study, we discuss the molecular pathway of each type of cell death and review the literature that has identified their role in IVDD. We also summarize the recent advances in targeted therapy at the RNA level, including RNA modulations through RNA interference and regulation of non-coding RNAs, for preventing cell death and subsequent IVDD. Therefore, we review the causes and possible therapeutic targets for RNA intervention and discuss the future direction of this research field.
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spelling pubmed-88342582022-02-12 Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review Ohnishi, Takashi Iwasaki, Norimasa Sudo, Hideki Cells Review Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms indirectly. Numerous studies have been performed to date, and the major strategy for all treatments of IVDD is to prevent cell loss due to programmed or regulated cell death. Accumulating evidence suggests that several types of cell death other than apoptosis, including necroptosis, pyroptosis, and ferroptosis, are also involved in IVDD. In this study, we discuss the molecular pathway of each type of cell death and review the literature that has identified their role in IVDD. We also summarize the recent advances in targeted therapy at the RNA level, including RNA modulations through RNA interference and regulation of non-coding RNAs, for preventing cell death and subsequent IVDD. Therefore, we review the causes and possible therapeutic targets for RNA intervention and discuss the future direction of this research field. MDPI 2022-01-24 /pmc/articles/PMC8834258/ /pubmed/35159202 http://dx.doi.org/10.3390/cells11030394 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ohnishi, Takashi
Iwasaki, Norimasa
Sudo, Hideki
Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review
title Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review
title_full Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review
title_fullStr Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review
title_full_unstemmed Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review
title_short Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review
title_sort causes of and molecular targets for the treatment of intervertebral disc degeneration: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834258/
https://www.ncbi.nlm.nih.gov/pubmed/35159202
http://dx.doi.org/10.3390/cells11030394
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