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Biomarker Development in Cardiology: Reviewing the Past to Inform the Future
Cardiac biomarkers have become pivotal to the clinical practice of cardiology, but there remains much to discover that could benefit cardiology patients. We review the discovery of key protein biomarkers in the fields of acute coronary syndrome, heart failure, and atherosclerosis, giving an overview...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834296/ https://www.ncbi.nlm.nih.gov/pubmed/35159397 http://dx.doi.org/10.3390/cells11030588 |
| _version_ | 1784649152053903360 |
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| author | Kott, Katharine A. Bishop, Michael Yang, Christina H. J. Plasto, Toby M. Cheng, Daniel C. Kaplan, Adam I. Cullen, Louise Celermajer, David S. Meikle, Peter J. Vernon, Stephen T. Figtree, Gemma A. |
| author_facet | Kott, Katharine A. Bishop, Michael Yang, Christina H. J. Plasto, Toby M. Cheng, Daniel C. Kaplan, Adam I. Cullen, Louise Celermajer, David S. Meikle, Peter J. Vernon, Stephen T. Figtree, Gemma A. |
| author_sort | Kott, Katharine A. |
| collection | PubMed |
| description | Cardiac biomarkers have become pivotal to the clinical practice of cardiology, but there remains much to discover that could benefit cardiology patients. We review the discovery of key protein biomarkers in the fields of acute coronary syndrome, heart failure, and atherosclerosis, giving an overview of the populations they were studied in and the statistics that were used to validate them. We review statistical approaches that are currently in use to assess new biomarkers and overview a framework for biomarker discovery and evaluation that could be incorporated into clinical trials to evaluate cardiovascular outcomes in the future. |
| format | Online Article Text |
| id | pubmed-8834296 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-88342962022-02-12 Biomarker Development in Cardiology: Reviewing the Past to Inform the Future Kott, Katharine A. Bishop, Michael Yang, Christina H. J. Plasto, Toby M. Cheng, Daniel C. Kaplan, Adam I. Cullen, Louise Celermajer, David S. Meikle, Peter J. Vernon, Stephen T. Figtree, Gemma A. Cells Review Cardiac biomarkers have become pivotal to the clinical practice of cardiology, but there remains much to discover that could benefit cardiology patients. We review the discovery of key protein biomarkers in the fields of acute coronary syndrome, heart failure, and atherosclerosis, giving an overview of the populations they were studied in and the statistics that were used to validate them. We review statistical approaches that are currently in use to assess new biomarkers and overview a framework for biomarker discovery and evaluation that could be incorporated into clinical trials to evaluate cardiovascular outcomes in the future. MDPI 2022-02-08 /pmc/articles/PMC8834296/ /pubmed/35159397 http://dx.doi.org/10.3390/cells11030588 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Kott, Katharine A. Bishop, Michael Yang, Christina H. J. Plasto, Toby M. Cheng, Daniel C. Kaplan, Adam I. Cullen, Louise Celermajer, David S. Meikle, Peter J. Vernon, Stephen T. Figtree, Gemma A. Biomarker Development in Cardiology: Reviewing the Past to Inform the Future |
| title | Biomarker Development in Cardiology: Reviewing the Past to Inform the Future |
| title_full | Biomarker Development in Cardiology: Reviewing the Past to Inform the Future |
| title_fullStr | Biomarker Development in Cardiology: Reviewing the Past to Inform the Future |
| title_full_unstemmed | Biomarker Development in Cardiology: Reviewing the Past to Inform the Future |
| title_short | Biomarker Development in Cardiology: Reviewing the Past to Inform the Future |
| title_sort | biomarker development in cardiology: reviewing the past to inform the future |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834296/ https://www.ncbi.nlm.nih.gov/pubmed/35159397 http://dx.doi.org/10.3390/cells11030588 |
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