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Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait

SIMPLE SUMMARY: Most men with prostate cancer will live as long as those who do not have prostate cancer. However, some men will die early of their disease due to a particular type of prostate cancer associated with recurrence and metastasis: intraductal carcinoma of the prostate. In this review, we...

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Autores principales: Pantazopoulos, Helen, Diop, Mame-Kany, Grosset, Andrée-Anne, Rouleau-Gagné, Frédérique, Al-Saleh, Afnan, Boblea, Teodora, Trudel, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834356/
https://www.ncbi.nlm.nih.gov/pubmed/35159086
http://dx.doi.org/10.3390/cancers14030820
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author Pantazopoulos, Helen
Diop, Mame-Kany
Grosset, Andrée-Anne
Rouleau-Gagné, Frédérique
Al-Saleh, Afnan
Boblea, Teodora
Trudel, Dominique
author_facet Pantazopoulos, Helen
Diop, Mame-Kany
Grosset, Andrée-Anne
Rouleau-Gagné, Frédérique
Al-Saleh, Afnan
Boblea, Teodora
Trudel, Dominique
author_sort Pantazopoulos, Helen
collection PubMed
description SIMPLE SUMMARY: Most men with prostate cancer will live as long as those who do not have prostate cancer. However, some men will die early of their disease due to a particular type of prostate cancer associated with recurrence and metastasis: intraductal carcinoma of the prostate. In this review, we discuss the associations between intraductal carcinoma of the prostate and metastasis, and the contemporary knowledge about the molecular alterations of intraductal carcinoma of the prostate. ABSTRACT: Intraductal carcinoma of the prostate (IDC-P) is one of the most aggressive types of prostate cancer (PCa). IDC-P is identified in approximately 20% of PCa patients and is associated with recurrence, metastasis, and PCa-specific death. The main feature of this histological variant is the colonization of benign glands by PCa cells. Although IDC-P is a well-recognized independent parameter for metastasis, mechanisms by which IDC-P cells can spread and colonize other tissues are not fully known. In this review, we discuss the molecular portraits of IDC-P determined by immunohistochemistry and genomic approaches and highlight the areas in which more research is needed.
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spelling pubmed-88343562022-02-12 Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait Pantazopoulos, Helen Diop, Mame-Kany Grosset, Andrée-Anne Rouleau-Gagné, Frédérique Al-Saleh, Afnan Boblea, Teodora Trudel, Dominique Cancers (Basel) Review SIMPLE SUMMARY: Most men with prostate cancer will live as long as those who do not have prostate cancer. However, some men will die early of their disease due to a particular type of prostate cancer associated with recurrence and metastasis: intraductal carcinoma of the prostate. In this review, we discuss the associations between intraductal carcinoma of the prostate and metastasis, and the contemporary knowledge about the molecular alterations of intraductal carcinoma of the prostate. ABSTRACT: Intraductal carcinoma of the prostate (IDC-P) is one of the most aggressive types of prostate cancer (PCa). IDC-P is identified in approximately 20% of PCa patients and is associated with recurrence, metastasis, and PCa-specific death. The main feature of this histological variant is the colonization of benign glands by PCa cells. Although IDC-P is a well-recognized independent parameter for metastasis, mechanisms by which IDC-P cells can spread and colonize other tissues are not fully known. In this review, we discuss the molecular portraits of IDC-P determined by immunohistochemistry and genomic approaches and highlight the areas in which more research is needed. MDPI 2022-02-06 /pmc/articles/PMC8834356/ /pubmed/35159086 http://dx.doi.org/10.3390/cancers14030820 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pantazopoulos, Helen
Diop, Mame-Kany
Grosset, Andrée-Anne
Rouleau-Gagné, Frédérique
Al-Saleh, Afnan
Boblea, Teodora
Trudel, Dominique
Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait
title Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait
title_full Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait
title_fullStr Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait
title_full_unstemmed Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait
title_short Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait
title_sort intraductal carcinoma of the prostate as a cause of prostate cancer metastasis: a molecular portrait
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834356/
https://www.ncbi.nlm.nih.gov/pubmed/35159086
http://dx.doi.org/10.3390/cancers14030820
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