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HIF-1α Stabilization in Flagellin-Stimulated Human Bronchial Cells Impairs Barrier Function

The respiratory epithelium provides a first line of defense against pathogens. Hypoxia-inducible factor (HIF)1α is a transcription factor which is stabilized in hypoxic conditions through the inhibition of prolyl-hydroxylase (PHD)2, the enzyme that marks HIF1α for degradation. Here, we studied the i...

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Detalles Bibliográficos
Autores principales:	Ramirez-Moral, Ivan, Ferreira, Bianca L., Butler, Joe M., van Weeghel, Michel, Otto, Natasja A., de Vos, Alex F., Yu, Xiao, de Jong, Menno D., Houtkooper, Riekelt H., van der Poll, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834373/ https://www.ncbi.nlm.nih.gov/pubmed/35159204 http://dx.doi.org/10.3390/cells11030391

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