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Golgi Apparatus Regulates Plasma Membrane Composition and Function
Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834378/ https://www.ncbi.nlm.nih.gov/pubmed/35159178 http://dx.doi.org/10.3390/cells11030368 |
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author | Agliarulo, Ilenia Parashuraman, Seetharaman |
author_facet | Agliarulo, Ilenia Parashuraman, Seetharaman |
author_sort | Agliarulo, Ilenia |
collection | PubMed |
description | Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-vesicular transport of lipids; and (c) vesicular sorting of proteins and lipids at the trans-Golgi network to target them to appropriate compartments. We discuss the molecules involved in these processes and their importance in physiology and development. We also discuss how mutations in these molecules affect plasma membrane composition and signaling leading to genetic diseases and cancer. |
format | Online Article Text |
id | pubmed-8834378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88343782022-02-12 Golgi Apparatus Regulates Plasma Membrane Composition and Function Agliarulo, Ilenia Parashuraman, Seetharaman Cells Review Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-vesicular transport of lipids; and (c) vesicular sorting of proteins and lipids at the trans-Golgi network to target them to appropriate compartments. We discuss the molecules involved in these processes and their importance in physiology and development. We also discuss how mutations in these molecules affect plasma membrane composition and signaling leading to genetic diseases and cancer. MDPI 2022-01-22 /pmc/articles/PMC8834378/ /pubmed/35159178 http://dx.doi.org/10.3390/cells11030368 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Agliarulo, Ilenia Parashuraman, Seetharaman Golgi Apparatus Regulates Plasma Membrane Composition and Function |
title | Golgi Apparatus Regulates Plasma Membrane Composition and Function |
title_full | Golgi Apparatus Regulates Plasma Membrane Composition and Function |
title_fullStr | Golgi Apparatus Regulates Plasma Membrane Composition and Function |
title_full_unstemmed | Golgi Apparatus Regulates Plasma Membrane Composition and Function |
title_short | Golgi Apparatus Regulates Plasma Membrane Composition and Function |
title_sort | golgi apparatus regulates plasma membrane composition and function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834378/ https://www.ncbi.nlm.nih.gov/pubmed/35159178 http://dx.doi.org/10.3390/cells11030368 |
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