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Golgi Apparatus Regulates Plasma Membrane Composition and Function

Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-...

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Detalles Bibliográficos
Autores principales: Agliarulo, Ilenia, Parashuraman, Seetharaman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834378/
https://www.ncbi.nlm.nih.gov/pubmed/35159178
http://dx.doi.org/10.3390/cells11030368
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author Agliarulo, Ilenia
Parashuraman, Seetharaman
author_facet Agliarulo, Ilenia
Parashuraman, Seetharaman
author_sort Agliarulo, Ilenia
collection PubMed
description Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-vesicular transport of lipids; and (c) vesicular sorting of proteins and lipids at the trans-Golgi network to target them to appropriate compartments. We discuss the molecules involved in these processes and their importance in physiology and development. We also discuss how mutations in these molecules affect plasma membrane composition and signaling leading to genetic diseases and cancer.
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spelling pubmed-88343782022-02-12 Golgi Apparatus Regulates Plasma Membrane Composition and Function Agliarulo, Ilenia Parashuraman, Seetharaman Cells Review Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-vesicular transport of lipids; and (c) vesicular sorting of proteins and lipids at the trans-Golgi network to target them to appropriate compartments. We discuss the molecules involved in these processes and their importance in physiology and development. We also discuss how mutations in these molecules affect plasma membrane composition and signaling leading to genetic diseases and cancer. MDPI 2022-01-22 /pmc/articles/PMC8834378/ /pubmed/35159178 http://dx.doi.org/10.3390/cells11030368 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Agliarulo, Ilenia
Parashuraman, Seetharaman
Golgi Apparatus Regulates Plasma Membrane Composition and Function
title Golgi Apparatus Regulates Plasma Membrane Composition and Function
title_full Golgi Apparatus Regulates Plasma Membrane Composition and Function
title_fullStr Golgi Apparatus Regulates Plasma Membrane Composition and Function
title_full_unstemmed Golgi Apparatus Regulates Plasma Membrane Composition and Function
title_short Golgi Apparatus Regulates Plasma Membrane Composition and Function
title_sort golgi apparatus regulates plasma membrane composition and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834378/
https://www.ncbi.nlm.nih.gov/pubmed/35159178
http://dx.doi.org/10.3390/cells11030368
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