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Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives
Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834417/ https://www.ncbi.nlm.nih.gov/pubmed/35159363 http://dx.doi.org/10.3390/cells11030554 |
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author | Boyer, Thomas Blaye, Céline Larmonier, Nicolas Domblides, Charlotte |
author_facet | Boyer, Thomas Blaye, Céline Larmonier, Nicolas Domblides, Charlotte |
author_sort | Boyer, Thomas |
collection | PubMed |
description | Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor cells and the immune escape are two major hallmarks of cancer, with several instances of crosstalk between them. In this paper, we review the effects of tumor metabolism on immune cells, focusing on myeloid cells due to their important role in tumorigenesis and immunosuppression from the early stages of the disease. We also discuss ways to target this specific crosstalk in cancer patients. |
format | Online Article Text |
id | pubmed-8834417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88344172022-02-12 Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives Boyer, Thomas Blaye, Céline Larmonier, Nicolas Domblides, Charlotte Cells Review Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor cells and the immune escape are two major hallmarks of cancer, with several instances of crosstalk between them. In this paper, we review the effects of tumor metabolism on immune cells, focusing on myeloid cells due to their important role in tumorigenesis and immunosuppression from the early stages of the disease. We also discuss ways to target this specific crosstalk in cancer patients. MDPI 2022-02-05 /pmc/articles/PMC8834417/ /pubmed/35159363 http://dx.doi.org/10.3390/cells11030554 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boyer, Thomas Blaye, Céline Larmonier, Nicolas Domblides, Charlotte Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives |
title | Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives |
title_full | Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives |
title_fullStr | Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives |
title_full_unstemmed | Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives |
title_short | Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives |
title_sort | influence of the metabolism on myeloid cell functions in cancers: clinical perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834417/ https://www.ncbi.nlm.nih.gov/pubmed/35159363 http://dx.doi.org/10.3390/cells11030554 |
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