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Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives

Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor...

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Detalles Bibliográficos
Autores principales: Boyer, Thomas, Blaye, Céline, Larmonier, Nicolas, Domblides, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834417/
https://www.ncbi.nlm.nih.gov/pubmed/35159363
http://dx.doi.org/10.3390/cells11030554
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author Boyer, Thomas
Blaye, Céline
Larmonier, Nicolas
Domblides, Charlotte
author_facet Boyer, Thomas
Blaye, Céline
Larmonier, Nicolas
Domblides, Charlotte
author_sort Boyer, Thomas
collection PubMed
description Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor cells and the immune escape are two major hallmarks of cancer, with several instances of crosstalk between them. In this paper, we review the effects of tumor metabolism on immune cells, focusing on myeloid cells due to their important role in tumorigenesis and immunosuppression from the early stages of the disease. We also discuss ways to target this specific crosstalk in cancer patients.
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spelling pubmed-88344172022-02-12 Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives Boyer, Thomas Blaye, Céline Larmonier, Nicolas Domblides, Charlotte Cells Review Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor cells and the immune escape are two major hallmarks of cancer, with several instances of crosstalk between them. In this paper, we review the effects of tumor metabolism on immune cells, focusing on myeloid cells due to their important role in tumorigenesis and immunosuppression from the early stages of the disease. We also discuss ways to target this specific crosstalk in cancer patients. MDPI 2022-02-05 /pmc/articles/PMC8834417/ /pubmed/35159363 http://dx.doi.org/10.3390/cells11030554 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boyer, Thomas
Blaye, Céline
Larmonier, Nicolas
Domblides, Charlotte
Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives
title Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives
title_full Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives
title_fullStr Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives
title_full_unstemmed Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives
title_short Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives
title_sort influence of the metabolism on myeloid cell functions in cancers: clinical perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834417/
https://www.ncbi.nlm.nih.gov/pubmed/35159363
http://dx.doi.org/10.3390/cells11030554
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AT domblidescharlotte influenceofthemetabolismonmyeloidcellfunctionsincancersclinicalperspectives