Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells

Carboxypeptidase A3 (CPA3) is a specific mast cell (MC) protease with variable expression. This protease is one of the preformed components of the secretome. During maturation of granules, CPA3 becomes an active enzyme with a characteristic localization determining the features of the cytological an...

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Autores principales: Atiakshin, Dmitri, Kostin, Andrey, Trotsenko, Ivan, Samoilova, Vera, Buchwalow, Igor, Tiemann, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834431/
https://www.ncbi.nlm.nih.gov/pubmed/35159379
http://dx.doi.org/10.3390/cells11030570
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author Atiakshin, Dmitri
Kostin, Andrey
Trotsenko, Ivan
Samoilova, Vera
Buchwalow, Igor
Tiemann, Markus
author_facet Atiakshin, Dmitri
Kostin, Andrey
Trotsenko, Ivan
Samoilova, Vera
Buchwalow, Igor
Tiemann, Markus
author_sort Atiakshin, Dmitri
collection PubMed
description Carboxypeptidase A3 (CPA3) is a specific mast cell (MC) protease with variable expression. This protease is one of the preformed components of the secretome. During maturation of granules, CPA3 becomes an active enzyme with a characteristic localization determining the features of the cytological and ultrastructural phenotype of MC. CPA3 takes part in the regulation of a specific tissue microenvironment, affecting the implementation of innate immunity, the mechanisms of angiogenesis, the processes of remodeling of the extracellular matrix, etc. Characterization of CPA3 expression in MC can be used to refine the MC classification, help in a prognosis, and increase the effectiveness of targeted therapy.
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spelling pubmed-88344312022-02-12 Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells Atiakshin, Dmitri Kostin, Andrey Trotsenko, Ivan Samoilova, Vera Buchwalow, Igor Tiemann, Markus Cells Review Carboxypeptidase A3 (CPA3) is a specific mast cell (MC) protease with variable expression. This protease is one of the preformed components of the secretome. During maturation of granules, CPA3 becomes an active enzyme with a characteristic localization determining the features of the cytological and ultrastructural phenotype of MC. CPA3 takes part in the regulation of a specific tissue microenvironment, affecting the implementation of innate immunity, the mechanisms of angiogenesis, the processes of remodeling of the extracellular matrix, etc. Characterization of CPA3 expression in MC can be used to refine the MC classification, help in a prognosis, and increase the effectiveness of targeted therapy. MDPI 2022-02-06 /pmc/articles/PMC8834431/ /pubmed/35159379 http://dx.doi.org/10.3390/cells11030570 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Atiakshin, Dmitri
Kostin, Andrey
Trotsenko, Ivan
Samoilova, Vera
Buchwalow, Igor
Tiemann, Markus
Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells
title Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells
title_full Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells
title_fullStr Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells
title_full_unstemmed Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells
title_short Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells
title_sort carboxypeptidase a3—a key component of the protease phenotype of mast cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834431/
https://www.ncbi.nlm.nih.gov/pubmed/35159379
http://dx.doi.org/10.3390/cells11030570
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