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Mechanical Regulation of Limb Bud Formation
Early limb bud development has been of considerable interest for the study of embryological development and especially morphogenesis. The focus has long been on biochemical signalling and less on cell biomechanics and mechanobiology. However, their importance cannot be understated since tissue shape...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834596/ https://www.ncbi.nlm.nih.gov/pubmed/35159230 http://dx.doi.org/10.3390/cells11030420 |
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author | Sermeus, Yvenn Vangheel, Jef Geris, Liesbet Smeets, Bart Tylzanowski, Przemko |
author_facet | Sermeus, Yvenn Vangheel, Jef Geris, Liesbet Smeets, Bart Tylzanowski, Przemko |
author_sort | Sermeus, Yvenn |
collection | PubMed |
description | Early limb bud development has been of considerable interest for the study of embryological development and especially morphogenesis. The focus has long been on biochemical signalling and less on cell biomechanics and mechanobiology. However, their importance cannot be understated since tissue shape changes are ultimately controlled by active forces and bulk tissue rheological properties that in turn depend on cell–cell interactions as well as extracellular matrix composition. Moreover, the feedback between gene regulation and the biomechanical environment is still poorly understood. In recent years, novel experimental techniques and computational models have reinvigorated research on this biomechanical and mechanobiological side of embryological development. In this review, we consider three stages of early limb development, namely: outgrowth, elongation, and condensation. For each of these stages, we summarize basic biological regulation and examine the role of cellular and tissue mechanics in the morphogenetic process. |
format | Online Article Text |
id | pubmed-8834596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88345962022-02-12 Mechanical Regulation of Limb Bud Formation Sermeus, Yvenn Vangheel, Jef Geris, Liesbet Smeets, Bart Tylzanowski, Przemko Cells Review Early limb bud development has been of considerable interest for the study of embryological development and especially morphogenesis. The focus has long been on biochemical signalling and less on cell biomechanics and mechanobiology. However, their importance cannot be understated since tissue shape changes are ultimately controlled by active forces and bulk tissue rheological properties that in turn depend on cell–cell interactions as well as extracellular matrix composition. Moreover, the feedback between gene regulation and the biomechanical environment is still poorly understood. In recent years, novel experimental techniques and computational models have reinvigorated research on this biomechanical and mechanobiological side of embryological development. In this review, we consider three stages of early limb development, namely: outgrowth, elongation, and condensation. For each of these stages, we summarize basic biological regulation and examine the role of cellular and tissue mechanics in the morphogenetic process. MDPI 2022-01-26 /pmc/articles/PMC8834596/ /pubmed/35159230 http://dx.doi.org/10.3390/cells11030420 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sermeus, Yvenn Vangheel, Jef Geris, Liesbet Smeets, Bart Tylzanowski, Przemko Mechanical Regulation of Limb Bud Formation |
title | Mechanical Regulation of Limb Bud Formation |
title_full | Mechanical Regulation of Limb Bud Formation |
title_fullStr | Mechanical Regulation of Limb Bud Formation |
title_full_unstemmed | Mechanical Regulation of Limb Bud Formation |
title_short | Mechanical Regulation of Limb Bud Formation |
title_sort | mechanical regulation of limb bud formation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834596/ https://www.ncbi.nlm.nih.gov/pubmed/35159230 http://dx.doi.org/10.3390/cells11030420 |
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