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Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers

Colorectal cancer (CRC) is the third most common cancer worldwide. The incidence and mortality rates of CRC are significantly higher in Taiwan than in other developed countries. Genes involved in CRC tumorigenesis differ depending on whether the tumor occurs on the left or right side of the colon, a...

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Autores principales: Su, Ming-Wei, Chang, Chung-Ke, Lin, Chien-Wei, Chu, Hou-Wei, Tsai, Tsen-Ni, Su, Wei-Chih, Chen, Yen-Cheng, Chang, Tsung-Kun, Huang, Ching-Wen, Tsai, Hsiang-Lin, Wu, Chang-Chieh, Chou, Huang-Chi, Shiu, Bei-Hao, Wang, Jaw-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834628/
https://www.ncbi.nlm.nih.gov/pubmed/35159336
http://dx.doi.org/10.3390/cells11030527
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author Su, Ming-Wei
Chang, Chung-Ke
Lin, Chien-Wei
Chu, Hou-Wei
Tsai, Tsen-Ni
Su, Wei-Chih
Chen, Yen-Cheng
Chang, Tsung-Kun
Huang, Ching-Wen
Tsai, Hsiang-Lin
Wu, Chang-Chieh
Chou, Huang-Chi
Shiu, Bei-Hao
Wang, Jaw-Yuan
author_facet Su, Ming-Wei
Chang, Chung-Ke
Lin, Chien-Wei
Chu, Hou-Wei
Tsai, Tsen-Ni
Su, Wei-Chih
Chen, Yen-Cheng
Chang, Tsung-Kun
Huang, Ching-Wen
Tsai, Hsiang-Lin
Wu, Chang-Chieh
Chou, Huang-Chi
Shiu, Bei-Hao
Wang, Jaw-Yuan
author_sort Su, Ming-Wei
collection PubMed
description Colorectal cancer (CRC) is the third most common cancer worldwide. The incidence and mortality rates of CRC are significantly higher in Taiwan than in other developed countries. Genes involved in CRC tumorigenesis differ depending on whether the tumor occurs on the left or right side of the colon, and genomic analysis is a keystone in the study and treatment of CRC subtypes. However, few studies have focused on the genetic landscape of Taiwanese patients with CRC. This study comprehensively analyzed the genomes of 141 Taiwanese patients with CRC through whole-exome sequencing. Significant genomic differences related to the site of CRC development were observed. Blood metabolomic profiling and polygenic risk score analysis were performed to identify potential biomarkers for the early identification and prevention of CRC in the Taiwanese population. Our findings provide vital clues for establishing population-specific treatments and health policies for CRC prevention in Taiwan.
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spelling pubmed-88346282022-02-12 Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers Su, Ming-Wei Chang, Chung-Ke Lin, Chien-Wei Chu, Hou-Wei Tsai, Tsen-Ni Su, Wei-Chih Chen, Yen-Cheng Chang, Tsung-Kun Huang, Ching-Wen Tsai, Hsiang-Lin Wu, Chang-Chieh Chou, Huang-Chi Shiu, Bei-Hao Wang, Jaw-Yuan Cells Article Colorectal cancer (CRC) is the third most common cancer worldwide. The incidence and mortality rates of CRC are significantly higher in Taiwan than in other developed countries. Genes involved in CRC tumorigenesis differ depending on whether the tumor occurs on the left or right side of the colon, and genomic analysis is a keystone in the study and treatment of CRC subtypes. However, few studies have focused on the genetic landscape of Taiwanese patients with CRC. This study comprehensively analyzed the genomes of 141 Taiwanese patients with CRC through whole-exome sequencing. Significant genomic differences related to the site of CRC development were observed. Blood metabolomic profiling and polygenic risk score analysis were performed to identify potential biomarkers for the early identification and prevention of CRC in the Taiwanese population. Our findings provide vital clues for establishing population-specific treatments and health policies for CRC prevention in Taiwan. MDPI 2022-02-03 /pmc/articles/PMC8834628/ /pubmed/35159336 http://dx.doi.org/10.3390/cells11030527 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Ming-Wei
Chang, Chung-Ke
Lin, Chien-Wei
Chu, Hou-Wei
Tsai, Tsen-Ni
Su, Wei-Chih
Chen, Yen-Cheng
Chang, Tsung-Kun
Huang, Ching-Wen
Tsai, Hsiang-Lin
Wu, Chang-Chieh
Chou, Huang-Chi
Shiu, Bei-Hao
Wang, Jaw-Yuan
Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers
title Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers
title_full Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers
title_fullStr Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers
title_full_unstemmed Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers
title_short Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers
title_sort genomic and metabolomic landscape of right-sided and left-sided colorectal cancer: potential preventive biomarkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834628/
https://www.ncbi.nlm.nih.gov/pubmed/35159336
http://dx.doi.org/10.3390/cells11030527
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