Cargando…

Gestational Age, Newborn Metabolic Markers and Academic Achievement

Background: Gestational age is associated with greater school achievement and variation in newborn metabolic markers. Whether metabolic markers are related to gestational age differences in achievement is unknown. This study examines whether newborn metabolic markers are associated with gestational...

Descripción completa

Detalles Bibliográficos
Autor principal: Wehby, George L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834716/
https://www.ncbi.nlm.nih.gov/pubmed/35162571
http://dx.doi.org/10.3390/ijerph19031549
_version_ 1784649252620730368
author Wehby, George L.
author_facet Wehby, George L.
author_sort Wehby, George L.
collection PubMed
description Background: Gestational age is associated with greater school achievement and variation in newborn metabolic markers. Whether metabolic markers are related to gestational age differences in achievement is unknown. This study examines whether newborn metabolic markers are associated with gestational age differences in performance on standardized school tests. Methods: This retrospective cohort study linked birth certificates of children born in Iowa between 2002 and 2010 to newborn screening records and school tests between 2009 and 2018. The analytical sample includes up to 229,679 children and 973,247 child-grade observations. Regression models estimate the associations between gestational age and 37 newborn metabolic markers with national percentile ranking (NPR) scores on math, reading comprehension, and science tests. Results: An additional gestational week is associated with 0.6 (95% CI: 0.6, 0.7), 0.5 (95% CI: 0.4, 0.5), and 0.4 (95% CI: 0.4, 0.5) higher NPRs on math, reading, and science, respectively. Compared to full term children (37–44 weeks), preterm children (32–36 weeks) have 2.2 (95% CI: −2.6, −1.8), 1.5 (95% CI: −1.9, −1.1), and 1.0 (95% CI: −1.4, −0.7) lower NPRs on math, reading comprehension, and science. Very preterm children (20–31 weeks) have 8.3 (95% CI: −9.4, −7.2), 5.2 (95% CI: −6.2, −4.0), and 4.7 (95% CI: −5.6, −3.8) lower NPRs than full term children on math, reading, and science. Metabolic markers are associated with 27%, 36%, and 45% of gestational age differences in math, reading, and science scores, respectively, and over half of the difference in test scores between preterm or very preterm and full term children. Conclusions: Newborn metabolic markers are strongly related to gestational age differences in school test scores, suggesting that early metabolic differences are important markers of long-term child development.
format Online
Article
Text
id pubmed-8834716
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88347162022-02-12 Gestational Age, Newborn Metabolic Markers and Academic Achievement Wehby, George L. Int J Environ Res Public Health Article Background: Gestational age is associated with greater school achievement and variation in newborn metabolic markers. Whether metabolic markers are related to gestational age differences in achievement is unknown. This study examines whether newborn metabolic markers are associated with gestational age differences in performance on standardized school tests. Methods: This retrospective cohort study linked birth certificates of children born in Iowa between 2002 and 2010 to newborn screening records and school tests between 2009 and 2018. The analytical sample includes up to 229,679 children and 973,247 child-grade observations. Regression models estimate the associations between gestational age and 37 newborn metabolic markers with national percentile ranking (NPR) scores on math, reading comprehension, and science tests. Results: An additional gestational week is associated with 0.6 (95% CI: 0.6, 0.7), 0.5 (95% CI: 0.4, 0.5), and 0.4 (95% CI: 0.4, 0.5) higher NPRs on math, reading, and science, respectively. Compared to full term children (37–44 weeks), preterm children (32–36 weeks) have 2.2 (95% CI: −2.6, −1.8), 1.5 (95% CI: −1.9, −1.1), and 1.0 (95% CI: −1.4, −0.7) lower NPRs on math, reading comprehension, and science. Very preterm children (20–31 weeks) have 8.3 (95% CI: −9.4, −7.2), 5.2 (95% CI: −6.2, −4.0), and 4.7 (95% CI: −5.6, −3.8) lower NPRs than full term children on math, reading, and science. Metabolic markers are associated with 27%, 36%, and 45% of gestational age differences in math, reading, and science scores, respectively, and over half of the difference in test scores between preterm or very preterm and full term children. Conclusions: Newborn metabolic markers are strongly related to gestational age differences in school test scores, suggesting that early metabolic differences are important markers of long-term child development. MDPI 2022-01-29 /pmc/articles/PMC8834716/ /pubmed/35162571 http://dx.doi.org/10.3390/ijerph19031549 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wehby, George L.
Gestational Age, Newborn Metabolic Markers and Academic Achievement
title Gestational Age, Newborn Metabolic Markers and Academic Achievement
title_full Gestational Age, Newborn Metabolic Markers and Academic Achievement
title_fullStr Gestational Age, Newborn Metabolic Markers and Academic Achievement
title_full_unstemmed Gestational Age, Newborn Metabolic Markers and Academic Achievement
title_short Gestational Age, Newborn Metabolic Markers and Academic Achievement
title_sort gestational age, newborn metabolic markers and academic achievement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834716/
https://www.ncbi.nlm.nih.gov/pubmed/35162571
http://dx.doi.org/10.3390/ijerph19031549
work_keys_str_mv AT wehbygeorgel gestationalagenewbornmetabolicmarkersandacademicachievement