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A Community Outbreak of Legionnaires’ Disease with Two Strains of L. pneumophila Serogroup 1 Linked to an Aquatic Therapy Centre

An outbreak of Legionnaires’ disease affected 18 people in Montpellier, a town of the south of France, between December 2016 and July 2017. All cases were diagnosed by a positive urinary antigen test. No deaths were reported. Epidemiological, environmental and genomic investigations (nested Sequence...

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Autores principales: Rousseau, Cyril, Ginevra, Christophe, Simac, Leslie, Fiard, Noel, Vilhes, Karine, Ranc, Anne-Gaëlle, Jarraud, Sophie, Gornes, Hervé, Mouly, Damien, Campese, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834728/
https://www.ncbi.nlm.nih.gov/pubmed/35162143
http://dx.doi.org/10.3390/ijerph19031119
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author Rousseau, Cyril
Ginevra, Christophe
Simac, Leslie
Fiard, Noel
Vilhes, Karine
Ranc, Anne-Gaëlle
Jarraud, Sophie
Gornes, Hervé
Mouly, Damien
Campese, Christine
author_facet Rousseau, Cyril
Ginevra, Christophe
Simac, Leslie
Fiard, Noel
Vilhes, Karine
Ranc, Anne-Gaëlle
Jarraud, Sophie
Gornes, Hervé
Mouly, Damien
Campese, Christine
author_sort Rousseau, Cyril
collection PubMed
description An outbreak of Legionnaires’ disease affected 18 people in Montpellier, a town of the south of France, between December 2016 and July 2017. All cases were diagnosed by a positive urinary antigen test. No deaths were reported. Epidemiological, environmental and genomic investigations (nested Sequence-Based Typing (nSBT) and whole genome sequencing) were undertaken. For the cases for which we had information, four had a new isolate (ST2471), one had a different new isolate (ST2470), one had a genomic pattern compatible with the ST2471 identified by nSBT (flaA = 3), and one had a genomic pattern not compatible with two previous identified STs (pilE = 6). The analysis conducted on the pool of an aquatic therapy center revealed seven isolates of Legionella pneumophila. Whole genome analysis confirmed the link between the environmental and clinical isolates for both ST2470 and ST2471. As the outbreak occurred slowly, with several weeks between new cases, it was not possible to immediately identify a common source. The sixth case was the first to report having aquatic therapy care. Of the 18 cases, eight had attended the aquatic therapy center and the other 10 were inhabitants who lived, worked or walked close to the center. The main cause for this outbreak was the lack of facility maintenance. This investigation highlights the risk to public health of aquatic therapy centers for users and nearby populations, and emphasizes the need for risk reduction measures with specific guidelines to improve health and safety in aquatic facilities.
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spelling pubmed-88347282022-02-12 A Community Outbreak of Legionnaires’ Disease with Two Strains of L. pneumophila Serogroup 1 Linked to an Aquatic Therapy Centre Rousseau, Cyril Ginevra, Christophe Simac, Leslie Fiard, Noel Vilhes, Karine Ranc, Anne-Gaëlle Jarraud, Sophie Gornes, Hervé Mouly, Damien Campese, Christine Int J Environ Res Public Health Article An outbreak of Legionnaires’ disease affected 18 people in Montpellier, a town of the south of France, between December 2016 and July 2017. All cases were diagnosed by a positive urinary antigen test. No deaths were reported. Epidemiological, environmental and genomic investigations (nested Sequence-Based Typing (nSBT) and whole genome sequencing) were undertaken. For the cases for which we had information, four had a new isolate (ST2471), one had a different new isolate (ST2470), one had a genomic pattern compatible with the ST2471 identified by nSBT (flaA = 3), and one had a genomic pattern not compatible with two previous identified STs (pilE = 6). The analysis conducted on the pool of an aquatic therapy center revealed seven isolates of Legionella pneumophila. Whole genome analysis confirmed the link between the environmental and clinical isolates for both ST2470 and ST2471. As the outbreak occurred slowly, with several weeks between new cases, it was not possible to immediately identify a common source. The sixth case was the first to report having aquatic therapy care. Of the 18 cases, eight had attended the aquatic therapy center and the other 10 were inhabitants who lived, worked or walked close to the center. The main cause for this outbreak was the lack of facility maintenance. This investigation highlights the risk to public health of aquatic therapy centers for users and nearby populations, and emphasizes the need for risk reduction measures with specific guidelines to improve health and safety in aquatic facilities. MDPI 2022-01-20 /pmc/articles/PMC8834728/ /pubmed/35162143 http://dx.doi.org/10.3390/ijerph19031119 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rousseau, Cyril
Ginevra, Christophe
Simac, Leslie
Fiard, Noel
Vilhes, Karine
Ranc, Anne-Gaëlle
Jarraud, Sophie
Gornes, Hervé
Mouly, Damien
Campese, Christine
A Community Outbreak of Legionnaires’ Disease with Two Strains of L. pneumophila Serogroup 1 Linked to an Aquatic Therapy Centre
title A Community Outbreak of Legionnaires’ Disease with Two Strains of L. pneumophila Serogroup 1 Linked to an Aquatic Therapy Centre
title_full A Community Outbreak of Legionnaires’ Disease with Two Strains of L. pneumophila Serogroup 1 Linked to an Aquatic Therapy Centre
title_fullStr A Community Outbreak of Legionnaires’ Disease with Two Strains of L. pneumophila Serogroup 1 Linked to an Aquatic Therapy Centre
title_full_unstemmed A Community Outbreak of Legionnaires’ Disease with Two Strains of L. pneumophila Serogroup 1 Linked to an Aquatic Therapy Centre
title_short A Community Outbreak of Legionnaires’ Disease with Two Strains of L. pneumophila Serogroup 1 Linked to an Aquatic Therapy Centre
title_sort community outbreak of legionnaires’ disease with two strains of l. pneumophila serogroup 1 linked to an aquatic therapy centre
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834728/
https://www.ncbi.nlm.nih.gov/pubmed/35162143
http://dx.doi.org/10.3390/ijerph19031119
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