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Oestrogenic Regulation of Mitochondrial Dynamics
Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific manner. Mitochondria are one of the central t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834780/ https://www.ncbi.nlm.nih.gov/pubmed/35163044 http://dx.doi.org/10.3390/ijms23031118 |
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author | Beikoghli Kalkhoran, Siavash Kararigas, Georgios |
author_facet | Beikoghli Kalkhoran, Siavash Kararigas, Georgios |
author_sort | Beikoghli Kalkhoran, Siavash |
collection | PubMed |
description | Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific manner. Mitochondria are one of the central targets of E2, and their biogenesis and respiration are known to be modulated by E2. More recently, it has become apparent that E2 also regulates mitochondrial fusion–fission dynamics, thereby affecting cellular metabolism. The aim of this article is to discuss the regulatory pathways by which E2 orchestrates the activity of several components of mitochondrial dynamics in the cardiovascular and nervous systems in health and disease. We conclude that E2 regulates mitochondrial dynamics to maintain the mitochondrial network promoting mitochondrial fusion and attenuating mitochondrial fission in both the cardiovascular and nervous systems. |
format | Online Article Text |
id | pubmed-8834780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88347802022-02-12 Oestrogenic Regulation of Mitochondrial Dynamics Beikoghli Kalkhoran, Siavash Kararigas, Georgios Int J Mol Sci Review Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific manner. Mitochondria are one of the central targets of E2, and their biogenesis and respiration are known to be modulated by E2. More recently, it has become apparent that E2 also regulates mitochondrial fusion–fission dynamics, thereby affecting cellular metabolism. The aim of this article is to discuss the regulatory pathways by which E2 orchestrates the activity of several components of mitochondrial dynamics in the cardiovascular and nervous systems in health and disease. We conclude that E2 regulates mitochondrial dynamics to maintain the mitochondrial network promoting mitochondrial fusion and attenuating mitochondrial fission in both the cardiovascular and nervous systems. MDPI 2022-01-20 /pmc/articles/PMC8834780/ /pubmed/35163044 http://dx.doi.org/10.3390/ijms23031118 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Beikoghli Kalkhoran, Siavash Kararigas, Georgios Oestrogenic Regulation of Mitochondrial Dynamics |
title | Oestrogenic Regulation of Mitochondrial Dynamics |
title_full | Oestrogenic Regulation of Mitochondrial Dynamics |
title_fullStr | Oestrogenic Regulation of Mitochondrial Dynamics |
title_full_unstemmed | Oestrogenic Regulation of Mitochondrial Dynamics |
title_short | Oestrogenic Regulation of Mitochondrial Dynamics |
title_sort | oestrogenic regulation of mitochondrial dynamics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834780/ https://www.ncbi.nlm.nih.gov/pubmed/35163044 http://dx.doi.org/10.3390/ijms23031118 |
work_keys_str_mv | AT beikoghlikalkhoransiavash oestrogenicregulationofmitochondrialdynamics AT kararigasgeorgios oestrogenicregulationofmitochondrialdynamics |