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Oestrogenic Regulation of Mitochondrial Dynamics

Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific manner. Mitochondria are one of the central t...

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Autores principales: Beikoghli Kalkhoran, Siavash, Kararigas, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834780/
https://www.ncbi.nlm.nih.gov/pubmed/35163044
http://dx.doi.org/10.3390/ijms23031118
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author Beikoghli Kalkhoran, Siavash
Kararigas, Georgios
author_facet Beikoghli Kalkhoran, Siavash
Kararigas, Georgios
author_sort Beikoghli Kalkhoran, Siavash
collection PubMed
description Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific manner. Mitochondria are one of the central targets of E2, and their biogenesis and respiration are known to be modulated by E2. More recently, it has become apparent that E2 also regulates mitochondrial fusion–fission dynamics, thereby affecting cellular metabolism. The aim of this article is to discuss the regulatory pathways by which E2 orchestrates the activity of several components of mitochondrial dynamics in the cardiovascular and nervous systems in health and disease. We conclude that E2 regulates mitochondrial dynamics to maintain the mitochondrial network promoting mitochondrial fusion and attenuating mitochondrial fission in both the cardiovascular and nervous systems.
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spelling pubmed-88347802022-02-12 Oestrogenic Regulation of Mitochondrial Dynamics Beikoghli Kalkhoran, Siavash Kararigas, Georgios Int J Mol Sci Review Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific manner. Mitochondria are one of the central targets of E2, and their biogenesis and respiration are known to be modulated by E2. More recently, it has become apparent that E2 also regulates mitochondrial fusion–fission dynamics, thereby affecting cellular metabolism. The aim of this article is to discuss the regulatory pathways by which E2 orchestrates the activity of several components of mitochondrial dynamics in the cardiovascular and nervous systems in health and disease. We conclude that E2 regulates mitochondrial dynamics to maintain the mitochondrial network promoting mitochondrial fusion and attenuating mitochondrial fission in both the cardiovascular and nervous systems. MDPI 2022-01-20 /pmc/articles/PMC8834780/ /pubmed/35163044 http://dx.doi.org/10.3390/ijms23031118 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Beikoghli Kalkhoran, Siavash
Kararigas, Georgios
Oestrogenic Regulation of Mitochondrial Dynamics
title Oestrogenic Regulation of Mitochondrial Dynamics
title_full Oestrogenic Regulation of Mitochondrial Dynamics
title_fullStr Oestrogenic Regulation of Mitochondrial Dynamics
title_full_unstemmed Oestrogenic Regulation of Mitochondrial Dynamics
title_short Oestrogenic Regulation of Mitochondrial Dynamics
title_sort oestrogenic regulation of mitochondrial dynamics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834780/
https://www.ncbi.nlm.nih.gov/pubmed/35163044
http://dx.doi.org/10.3390/ijms23031118
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