The Ubiquitin E3 Ligase Nedd4 Regulates the Expression and Amyloid-β Peptide Export Activity of P-Glycoprotein

The ATP-binding cassette transporter, P-glycoprotein (P-gp), has been demonstrated to facilitate the clearance of amyloid-beta (Aβ) peptides, exporting the neurotoxic entity out of neurons and out of the brain via the blood–brain barrier. However, its expression and function diminish with age and in...

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Detalles Bibliográficos
Autores principales: Chai, Amanda B., Callaghan, Richard, Gelissen, Ingrid C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834788/
https://www.ncbi.nlm.nih.gov/pubmed/35162941
http://dx.doi.org/10.3390/ijms23031019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834788/
https://www.ncbi.nlm.nih.gov/pubmed/35162941
http://dx.doi.org/10.3390/ijms23031019

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