Cargando…

Cellular and Gene Expression Response to the Combination of Genistein and Kaempferol in the Treatment of Mucopolysaccharidosis Type I

Flavonoids are investigated as therapeutics for mucopolysaccharidosis, a metabolic disorder with impaired glycosaminoglycan degradation. Here we determined the effects of genistein and kaempferol, used alone or in combination, on cellular response and gene expression in a mucopolysaccharidosis type...

Descripción completa

Detalles Bibliográficos
Autores principales:	Węsierska, Magdalena, Kloska, Anna, Medina, Diego L., Jakóbkiewicz-Banecka, Joanna, Gabig-Cimińska, Magdalena, Radzińska, Marta, Moskot, Marta, Malinowska, Marcelina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834790/ https://www.ncbi.nlm.nih.gov/pubmed/35162981 http://dx.doi.org/10.3390/ijms23031058

Ejemplares similares

Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases
por: Kloska, Anna, et al.
Publicado: (2020)

The Role of Dimethyl Sulfoxide (DMSO) in Gene Expression Modulation and Glycosaminoglycan Metabolism in Lysosomal Storage Disorders on an Example of Mucopolysaccharidosis
por: Moskot, Marta, et al.
Publicado: (2019)

Murine Fibroblasts and Primary Hepatocytes as Tools When Studying the Efficacy of Potential Therapies for Mucopolysaccharidosis Type I
por: Węsierska, Magdalena, et al.
Publicado: (2022)

Lipids and Lipid Mediators Associated with the Risk and Pathology of Ischemic Stroke
por: Kloska, Anna, et al.
Publicado: (2020)

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
por: Bocheńska, Katarzyna, et al.
Publicado: (2021)

Synthetic genistein derivatives as modulators of glycosaminoglycan storage
por: Kloska, Anna, et al.
Publicado: (2012)

Corrigendum: Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
por: Moskot, Marta, et al.
Publicado: (2016)

Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
por: Moskot, Marta, et al.
Publicado: (2015)

Corrigendum: Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
por: Moskot, Marta, et al.
Publicado: (2016)

Molecular action of isoflavone genistein in the human epithelial cell line HaCaT
por: Smolińska, Elwira, et al.
Publicado: (2018)

Models in the Research Process of Psoriasis
por: Bocheńska, Katarzyna, et al.
Publicado: (2017)

Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders
por: Moskot, Marta, et al.
Publicado: (2018)

Nonsteroidal anti-inflammatory drugs modulate cellular glycosaminoglycan synthesis by affecting EGFR and PI3K signaling pathways
por: Mozolewski, Paweł, et al.
Publicado: (2017)

Lysosome Alterations in the Human Epithelial Cell Line HaCaT and Skin Specimens: Relevance to Psoriasis
por: Bocheńska, Katarzyna, et al.
Publicado: (2019)

Correction: Bocheńska, K. et al. Lysosome Alterations in the Human Epithelial Cell Line HaCaT and Skin Specimens: Relevance to Psoriasis. Int. J. Mol. Sci. 2019, 20, 2255
por: Bocheńska, Katarzyna, et al.
Publicado: (2020)

Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts
por: Moskot, Marta, et al.
Publicado: (2015)

Activities of genes controlling sphingolipid metabolism in human fibroblasts treated with flavonoids
por: Moskot, Marta, et al.
Publicado: (2015)

Factors and processes modulating phenotypes in neuronopathic lysosomal storage diseases
por: Jakóbkiewicz-Banecka, Joanna, et al.
Publicado: (2013)

Effect of Silicone on the Collagen Fibrillogenesis and Stability
por: Kadziński, Leszek, et al.
Publicado: (2015)

Use of Cytokine Mix-, Imiquimod-, and Serum-Induced Monoculture and Lipopolysaccharide- and Interferon Gamma-Treated Co-Culture to Establish In Vitro Psoriasis-like Inflammation Models
por: Bocheńska, Katarzyna, et al.
Publicado: (2021)

Molecular treatment trajectories within psoriatic T lymphocytes: a mini review
por: Kuczyńska, Martyna, et al.
Publicado: (2023)

The model homologue of the partially defective human 5,10-methylenetetrahydrofolate reductase, considered as a risk factor for stroke due to increased homocysteine level, can be protected and reactivated by heat shock proteins
por: Grabowski, Michał, et al.
Publicado: (2016)

Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses
por: Kloska, Anna, et al.
Publicado: (2011)

Global Changes of 5-mC/5h-mC Ratio and Methylation of Adiponectin and Leptin Gene in Placenta Depending on Mode of Delivery
por: Słabuszewska-Jóźwiak, Aneta, et al.
Publicado: (2021)

Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway
por: Jakóbkiewicz-Banecka, Joanna, et al.
Publicado: (2009)

Atypical microbial infections of digestive tract may contribute to diarrhea in mucopolysaccharidosis patients: a MPS I case study
por: Węgrzyn, Grzegorz, et al.
Publicado: (2005)

Developing nucleic acid-based electrical detection systems
por: Gabig-Ciminska, Magdalena
Publicado: (2006)

Dosage Compensation in Females with X-Linked Metabolic Disorders
por: Juchniewicz, Patrycja, et al.
Publicado: (2021)

Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis
por: Pleńkowska, Joanna, et al.
Publicado: (2020)

Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis
por: Bocheńska, Katarzyna, et al.
Publicado: (2020)

Editorial: Innovative integrated immuno—and inflammopharmacology in reference to autoimmune skin diseases
por: Gabig-Cimińska, Magdalena, et al.
Publicado: (2023)

Personalized prediction of the secondary oocytes number after ovarian stimulation: A machine learning model based on clinical and genetic data
por: Zieliński, Krystian, et al.
Publicado: (2023)

X-chromosome inactivation patterns depend on age and tissue but not conception method in humans
por: Juchniewicz, Patrycja, et al.
Publicado: (2023)

Two-year follow-up of Sanfilippo Disease patients treated with a genistein-rich isoflavone extract: Assessment of effects on cognitive functions and general status of patients
por: Piotrowska, Ewa, et al.
Publicado: (2011)

Sample processing for DNA chip array-based analysis of enterohemorrhagic Escherichia coli (EHEC)
por: Basselet, Pascal, et al.
Publicado: (2008)

Identification of pathogenic microbial cells and spores by electrochemical detection on a biochip
por: Gabig-Ciminska, Magdalena, et al.
Publicado: (2004)

A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents
por: Słomiński, Bartosz, et al.
Publicado: (2020)

Underestimated Aspect of Mucopolysaccharidosis Pathogenesis: Global Changes in Cellular Processes Revealed by Transcriptomic Studies
por: Gaffke, Lidia, et al.
Publicado: (2020)

ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland
por: Stawczyk-Macieja, Marta, et al.
Publicado: (2018)

Prevalence of polymorphisms in OPG, RANKL and RANK as potential markers for Charcot arthropathy development
por: Bruhn-Olszewska, Bożena, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pi3k9ini2ob77ucv06ceoiteaa