ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes

The unfolded protein response in the endoplasmic reticulum (UPR(ER)) is involved in a number of metabolic diseases. Here, we characterize UPR(ER)-induced metabolic changes in mouse livers in vivo through metabolic labeling and mass spectrometric analysis of lipid and proteome-wide fluxes. We induced...

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Detalles Bibliográficos
Autores principales: Ward, Catherine P., Peng, Lucy, Yuen, Samuel, Chang, Michael, Karapetyan, Rozalina, Nyangau, Edna, Mohammed, Hussein, Palacios, Hector, Ziari, Naveed, Joe, Larry K., Frakes, Ashley E., Dandan, Mohamad, Dillin, Andrew, Hellerstein, Marc K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835023/
https://www.ncbi.nlm.nih.gov/pubmed/35162995
http://dx.doi.org/10.3390/ijms23031073

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