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Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015

Limited data are available for how biomarkers of tobacco exposure (BOE) change when cigarette smokers transition to using electronic nicotine delivery systems (ENDS). Using biomarker data from Waves 1 (2013–2014) and 2 (2014–2015) of the PATH Study, we examined how mean BOE concentrations, including...

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Autores principales: Anic, Gabriella M., Rostron, Brian L., Hammad, Hoda T., van Bemmel, Dana M., Del Valle-Pinero, Arseima Y., Christensen, Carol H., Erives, Gladys, Faulcon, Lisa M., Blount, Benjamin C., Wang, Yuesong, Wang, Lanqing, Bhandari, Deepak, Calafat, Antonia M., Kimmel, Heather L., Everard, Colm D., Compton, Wilson M., Edwards, Kathryn C., Goniewicz, Maciej L., Wei, Binnian, Hyland, Andrew, Hatsukami, Dorothy K., Hecht, Stephen S., Niaura, Raymond S., Borek, Nicolette, Ambrose, Bridget K., Chang, Cindy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835100/
https://www.ncbi.nlm.nih.gov/pubmed/35162490
http://dx.doi.org/10.3390/ijerph19031462
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author Anic, Gabriella M.
Rostron, Brian L.
Hammad, Hoda T.
van Bemmel, Dana M.
Del Valle-Pinero, Arseima Y.
Christensen, Carol H.
Erives, Gladys
Faulcon, Lisa M.
Blount, Benjamin C.
Wang, Yuesong
Wang, Lanqing
Bhandari, Deepak
Calafat, Antonia M.
Kimmel, Heather L.
Everard, Colm D.
Compton, Wilson M.
Edwards, Kathryn C.
Goniewicz, Maciej L.
Wei, Binnian
Hyland, Andrew
Hatsukami, Dorothy K.
Hecht, Stephen S.
Niaura, Raymond S.
Borek, Nicolette
Ambrose, Bridget K.
Chang, Cindy M.
author_facet Anic, Gabriella M.
Rostron, Brian L.
Hammad, Hoda T.
van Bemmel, Dana M.
Del Valle-Pinero, Arseima Y.
Christensen, Carol H.
Erives, Gladys
Faulcon, Lisa M.
Blount, Benjamin C.
Wang, Yuesong
Wang, Lanqing
Bhandari, Deepak
Calafat, Antonia M.
Kimmel, Heather L.
Everard, Colm D.
Compton, Wilson M.
Edwards, Kathryn C.
Goniewicz, Maciej L.
Wei, Binnian
Hyland, Andrew
Hatsukami, Dorothy K.
Hecht, Stephen S.
Niaura, Raymond S.
Borek, Nicolette
Ambrose, Bridget K.
Chang, Cindy M.
author_sort Anic, Gabriella M.
collection PubMed
description Limited data are available for how biomarkers of tobacco exposure (BOE) change when cigarette smokers transition to using electronic nicotine delivery systems (ENDS). Using biomarker data from Waves 1 (2013–2014) and 2 (2014–2015) of the PATH Study, we examined how mean BOE concentrations, including metabolites of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), and volatile organic compounds (VOC) and metals, changed when 2475 adult smokers transitioned to using ENDS or quit tobacco products. Exclusive smokers who transitioned to dual use had a significant decrease in NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol), but not nicotine metabolites, most PAHs, metals, or VOCs. Exclusive smokers who became dual users had significant reductions in total nicotine equivalents, NNAL, and 2CyEMA (acrylonitrile metabolite), but only in those who reduced cigarettes per day (CPD) by >=50%. Smokers who transitioned to exclusive ENDS use had significant reductions in most TSNAs, PAHs, and VOCs; however, nicotine metabolites did not decrease in dual users who became exclusive ENDS users. Smokers who quit tobacco use had significant decreases in nicotine metabolites, all TSNAs, most PAHs, and most VOCs. Cigarette smokers who became dual users did not experience significant reductions in most BOEs. Reductions were impacted by changes in CPD. However, transitioning from smoking to no tobacco or exclusive ENDS use was associated with reduced exposure to most BOEs measured. Future analyses could incorporate additional waves of PATH data and examine changes in biomarker exposure by ENDS device type and CPD.
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spelling pubmed-88351002022-02-12 Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015 Anic, Gabriella M. Rostron, Brian L. Hammad, Hoda T. van Bemmel, Dana M. Del Valle-Pinero, Arseima Y. Christensen, Carol H. Erives, Gladys Faulcon, Lisa M. Blount, Benjamin C. Wang, Yuesong Wang, Lanqing Bhandari, Deepak Calafat, Antonia M. Kimmel, Heather L. Everard, Colm D. Compton, Wilson M. Edwards, Kathryn C. Goniewicz, Maciej L. Wei, Binnian Hyland, Andrew Hatsukami, Dorothy K. Hecht, Stephen S. Niaura, Raymond S. Borek, Nicolette Ambrose, Bridget K. Chang, Cindy M. Int J Environ Res Public Health Article Limited data are available for how biomarkers of tobacco exposure (BOE) change when cigarette smokers transition to using electronic nicotine delivery systems (ENDS). Using biomarker data from Waves 1 (2013–2014) and 2 (2014–2015) of the PATH Study, we examined how mean BOE concentrations, including metabolites of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), and volatile organic compounds (VOC) and metals, changed when 2475 adult smokers transitioned to using ENDS or quit tobacco products. Exclusive smokers who transitioned to dual use had a significant decrease in NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol), but not nicotine metabolites, most PAHs, metals, or VOCs. Exclusive smokers who became dual users had significant reductions in total nicotine equivalents, NNAL, and 2CyEMA (acrylonitrile metabolite), but only in those who reduced cigarettes per day (CPD) by >=50%. Smokers who transitioned to exclusive ENDS use had significant reductions in most TSNAs, PAHs, and VOCs; however, nicotine metabolites did not decrease in dual users who became exclusive ENDS users. Smokers who quit tobacco use had significant decreases in nicotine metabolites, all TSNAs, most PAHs, and most VOCs. Cigarette smokers who became dual users did not experience significant reductions in most BOEs. Reductions were impacted by changes in CPD. However, transitioning from smoking to no tobacco or exclusive ENDS use was associated with reduced exposure to most BOEs measured. Future analyses could incorporate additional waves of PATH data and examine changes in biomarker exposure by ENDS device type and CPD. MDPI 2022-01-27 /pmc/articles/PMC8835100/ /pubmed/35162490 http://dx.doi.org/10.3390/ijerph19031462 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anic, Gabriella M.
Rostron, Brian L.
Hammad, Hoda T.
van Bemmel, Dana M.
Del Valle-Pinero, Arseima Y.
Christensen, Carol H.
Erives, Gladys
Faulcon, Lisa M.
Blount, Benjamin C.
Wang, Yuesong
Wang, Lanqing
Bhandari, Deepak
Calafat, Antonia M.
Kimmel, Heather L.
Everard, Colm D.
Compton, Wilson M.
Edwards, Kathryn C.
Goniewicz, Maciej L.
Wei, Binnian
Hyland, Andrew
Hatsukami, Dorothy K.
Hecht, Stephen S.
Niaura, Raymond S.
Borek, Nicolette
Ambrose, Bridget K.
Chang, Cindy M.
Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015
title Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015
title_full Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015
title_fullStr Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015
title_full_unstemmed Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015
title_short Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015
title_sort changes in biomarkers of tobacco exposure among cigarette smokers transitioning to ends use: the population assessment of tobacco and health study, 2013–2015
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835100/
https://www.ncbi.nlm.nih.gov/pubmed/35162490
http://dx.doi.org/10.3390/ijerph19031462
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