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Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015
Limited data are available for how biomarkers of tobacco exposure (BOE) change when cigarette smokers transition to using electronic nicotine delivery systems (ENDS). Using biomarker data from Waves 1 (2013–2014) and 2 (2014–2015) of the PATH Study, we examined how mean BOE concentrations, including...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835100/ https://www.ncbi.nlm.nih.gov/pubmed/35162490 http://dx.doi.org/10.3390/ijerph19031462 |
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author | Anic, Gabriella M. Rostron, Brian L. Hammad, Hoda T. van Bemmel, Dana M. Del Valle-Pinero, Arseima Y. Christensen, Carol H. Erives, Gladys Faulcon, Lisa M. Blount, Benjamin C. Wang, Yuesong Wang, Lanqing Bhandari, Deepak Calafat, Antonia M. Kimmel, Heather L. Everard, Colm D. Compton, Wilson M. Edwards, Kathryn C. Goniewicz, Maciej L. Wei, Binnian Hyland, Andrew Hatsukami, Dorothy K. Hecht, Stephen S. Niaura, Raymond S. Borek, Nicolette Ambrose, Bridget K. Chang, Cindy M. |
author_facet | Anic, Gabriella M. Rostron, Brian L. Hammad, Hoda T. van Bemmel, Dana M. Del Valle-Pinero, Arseima Y. Christensen, Carol H. Erives, Gladys Faulcon, Lisa M. Blount, Benjamin C. Wang, Yuesong Wang, Lanqing Bhandari, Deepak Calafat, Antonia M. Kimmel, Heather L. Everard, Colm D. Compton, Wilson M. Edwards, Kathryn C. Goniewicz, Maciej L. Wei, Binnian Hyland, Andrew Hatsukami, Dorothy K. Hecht, Stephen S. Niaura, Raymond S. Borek, Nicolette Ambrose, Bridget K. Chang, Cindy M. |
author_sort | Anic, Gabriella M. |
collection | PubMed |
description | Limited data are available for how biomarkers of tobacco exposure (BOE) change when cigarette smokers transition to using electronic nicotine delivery systems (ENDS). Using biomarker data from Waves 1 (2013–2014) and 2 (2014–2015) of the PATH Study, we examined how mean BOE concentrations, including metabolites of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), and volatile organic compounds (VOC) and metals, changed when 2475 adult smokers transitioned to using ENDS or quit tobacco products. Exclusive smokers who transitioned to dual use had a significant decrease in NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol), but not nicotine metabolites, most PAHs, metals, or VOCs. Exclusive smokers who became dual users had significant reductions in total nicotine equivalents, NNAL, and 2CyEMA (acrylonitrile metabolite), but only in those who reduced cigarettes per day (CPD) by >=50%. Smokers who transitioned to exclusive ENDS use had significant reductions in most TSNAs, PAHs, and VOCs; however, nicotine metabolites did not decrease in dual users who became exclusive ENDS users. Smokers who quit tobacco use had significant decreases in nicotine metabolites, all TSNAs, most PAHs, and most VOCs. Cigarette smokers who became dual users did not experience significant reductions in most BOEs. Reductions were impacted by changes in CPD. However, transitioning from smoking to no tobacco or exclusive ENDS use was associated with reduced exposure to most BOEs measured. Future analyses could incorporate additional waves of PATH data and examine changes in biomarker exposure by ENDS device type and CPD. |
format | Online Article Text |
id | pubmed-8835100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88351002022-02-12 Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015 Anic, Gabriella M. Rostron, Brian L. Hammad, Hoda T. van Bemmel, Dana M. Del Valle-Pinero, Arseima Y. Christensen, Carol H. Erives, Gladys Faulcon, Lisa M. Blount, Benjamin C. Wang, Yuesong Wang, Lanqing Bhandari, Deepak Calafat, Antonia M. Kimmel, Heather L. Everard, Colm D. Compton, Wilson M. Edwards, Kathryn C. Goniewicz, Maciej L. Wei, Binnian Hyland, Andrew Hatsukami, Dorothy K. Hecht, Stephen S. Niaura, Raymond S. Borek, Nicolette Ambrose, Bridget K. Chang, Cindy M. Int J Environ Res Public Health Article Limited data are available for how biomarkers of tobacco exposure (BOE) change when cigarette smokers transition to using electronic nicotine delivery systems (ENDS). Using biomarker data from Waves 1 (2013–2014) and 2 (2014–2015) of the PATH Study, we examined how mean BOE concentrations, including metabolites of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), and volatile organic compounds (VOC) and metals, changed when 2475 adult smokers transitioned to using ENDS or quit tobacco products. Exclusive smokers who transitioned to dual use had a significant decrease in NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol), but not nicotine metabolites, most PAHs, metals, or VOCs. Exclusive smokers who became dual users had significant reductions in total nicotine equivalents, NNAL, and 2CyEMA (acrylonitrile metabolite), but only in those who reduced cigarettes per day (CPD) by >=50%. Smokers who transitioned to exclusive ENDS use had significant reductions in most TSNAs, PAHs, and VOCs; however, nicotine metabolites did not decrease in dual users who became exclusive ENDS users. Smokers who quit tobacco use had significant decreases in nicotine metabolites, all TSNAs, most PAHs, and most VOCs. Cigarette smokers who became dual users did not experience significant reductions in most BOEs. Reductions were impacted by changes in CPD. However, transitioning from smoking to no tobacco or exclusive ENDS use was associated with reduced exposure to most BOEs measured. Future analyses could incorporate additional waves of PATH data and examine changes in biomarker exposure by ENDS device type and CPD. MDPI 2022-01-27 /pmc/articles/PMC8835100/ /pubmed/35162490 http://dx.doi.org/10.3390/ijerph19031462 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Anic, Gabriella M. Rostron, Brian L. Hammad, Hoda T. van Bemmel, Dana M. Del Valle-Pinero, Arseima Y. Christensen, Carol H. Erives, Gladys Faulcon, Lisa M. Blount, Benjamin C. Wang, Yuesong Wang, Lanqing Bhandari, Deepak Calafat, Antonia M. Kimmel, Heather L. Everard, Colm D. Compton, Wilson M. Edwards, Kathryn C. Goniewicz, Maciej L. Wei, Binnian Hyland, Andrew Hatsukami, Dorothy K. Hecht, Stephen S. Niaura, Raymond S. Borek, Nicolette Ambrose, Bridget K. Chang, Cindy M. Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015 |
title | Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015 |
title_full | Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015 |
title_fullStr | Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015 |
title_full_unstemmed | Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015 |
title_short | Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015 |
title_sort | changes in biomarkers of tobacco exposure among cigarette smokers transitioning to ends use: the population assessment of tobacco and health study, 2013–2015 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835100/ https://www.ncbi.nlm.nih.gov/pubmed/35162490 http://dx.doi.org/10.3390/ijerph19031462 |
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