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High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS)
The hygiene hypothesis assumes a low incidence of allergic diseases in families engaging in farming work. However, a few studies have indicated rural life as a potential risk factor for atopic dermatitis (AD). Using a large Japanese birth cohort dataset, we calculated the accumulated incidence of AD...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835142/ https://www.ncbi.nlm.nih.gov/pubmed/35162784 http://dx.doi.org/10.3390/ijerph19031761 |
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author | Yokomichi, Hiroshi Mochizuki, Mie Kojima, Reiji Horiuchi, Sayaka Ooka, Tadao Akiyama, Yuka Miyake, Kunio Kushima, Megumi Otawa, Sanae Shinohara, Ryoji Yamagata, Zentaro |
author_facet | Yokomichi, Hiroshi Mochizuki, Mie Kojima, Reiji Horiuchi, Sayaka Ooka, Tadao Akiyama, Yuka Miyake, Kunio Kushima, Megumi Otawa, Sanae Shinohara, Ryoji Yamagata, Zentaro |
author_sort | Yokomichi, Hiroshi |
collection | PubMed |
description | The hygiene hypothesis assumes a low incidence of allergic diseases in families engaging in farming work. However, a few studies have indicated rural life as a potential risk factor for atopic dermatitis (AD). Using a large Japanese birth cohort dataset, we calculated the accumulated incidence of AD in children aged 6 months and 1, 2, and 3 years by family business and the hazard ratio. We adjusted for confounding factors. The father’s job was considered the family business. We analysed data on 41,469 father–child pairs at 6 months of age, 40,067 pairs at 1 year, 38,286 pairs at 2 years, and 36,570 pairs at 3 years. We found the highest accumulated incidence of AD among children with fathers engaged in primary industry, with 2.5% at the age of 6 months, 6.6% at 1 year, 12.0% at 2 years, and 15.4% at 3 years. Among primary industry occupations, forestry was associated with the highest incidence of AD across these ages. The hazard ratio of AD was also highest for children whose family business was primary industry. In conclusion, the highest incidence and hazard ratio of AD were observed among children whose fathers worked in primary industry. |
format | Online Article Text |
id | pubmed-8835142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88351422022-02-12 High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS) Yokomichi, Hiroshi Mochizuki, Mie Kojima, Reiji Horiuchi, Sayaka Ooka, Tadao Akiyama, Yuka Miyake, Kunio Kushima, Megumi Otawa, Sanae Shinohara, Ryoji Yamagata, Zentaro Int J Environ Res Public Health Article The hygiene hypothesis assumes a low incidence of allergic diseases in families engaging in farming work. However, a few studies have indicated rural life as a potential risk factor for atopic dermatitis (AD). Using a large Japanese birth cohort dataset, we calculated the accumulated incidence of AD in children aged 6 months and 1, 2, and 3 years by family business and the hazard ratio. We adjusted for confounding factors. The father’s job was considered the family business. We analysed data on 41,469 father–child pairs at 6 months of age, 40,067 pairs at 1 year, 38,286 pairs at 2 years, and 36,570 pairs at 3 years. We found the highest accumulated incidence of AD among children with fathers engaged in primary industry, with 2.5% at the age of 6 months, 6.6% at 1 year, 12.0% at 2 years, and 15.4% at 3 years. Among primary industry occupations, forestry was associated with the highest incidence of AD across these ages. The hazard ratio of AD was also highest for children whose family business was primary industry. In conclusion, the highest incidence and hazard ratio of AD were observed among children whose fathers worked in primary industry. MDPI 2022-02-03 /pmc/articles/PMC8835142/ /pubmed/35162784 http://dx.doi.org/10.3390/ijerph19031761 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yokomichi, Hiroshi Mochizuki, Mie Kojima, Reiji Horiuchi, Sayaka Ooka, Tadao Akiyama, Yuka Miyake, Kunio Kushima, Megumi Otawa, Sanae Shinohara, Ryoji Yamagata, Zentaro High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS) |
title | High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS) |
title_full | High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS) |
title_fullStr | High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS) |
title_full_unstemmed | High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS) |
title_short | High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS) |
title_sort | high incidence of atopic dermatitis among children whose fathers work in primary industry: the japan environment and children’s study (jecs) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835142/ https://www.ncbi.nlm.nih.gov/pubmed/35162784 http://dx.doi.org/10.3390/ijerph19031761 |
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