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Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study

BACKGROUND: Prenatal exposure to metals can affect the developing fetus and negatively impact neurobehavior. The associations between individual metals and neurodevelopment have been examined, but little work has explored the potentially detrimental neurodevelopmental outcomes associated with the co...

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Autores principales: Tung, Pei Wen, Burt, Amber, Karagas, Margaret, Jackson, Brian P., Punshon, Tracy, Lester, Barry, Marsit, Carmen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835549/
https://www.ncbi.nlm.nih.gov/pubmed/35169672
http://dx.doi.org/10.1097/EE9.0000000000000194
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author Tung, Pei Wen
Burt, Amber
Karagas, Margaret
Jackson, Brian P.
Punshon, Tracy
Lester, Barry
Marsit, Carmen J.
author_facet Tung, Pei Wen
Burt, Amber
Karagas, Margaret
Jackson, Brian P.
Punshon, Tracy
Lester, Barry
Marsit, Carmen J.
author_sort Tung, Pei Wen
collection PubMed
description BACKGROUND: Prenatal exposure to metals can affect the developing fetus and negatively impact neurobehavior. The associations between individual metals and neurodevelopment have been examined, but little work has explored the potentially detrimental neurodevelopmental outcomes associated with the combined impact of coexisting metals. The objective of this study is to evaluate prenatal metal exposure mixtures in the placenta to elucidate the link between their combined effects on newborn neurobehavior. METHOD: This study included 192 infants with available placental metal and NICU Network Neurobehavioral Scale data at 24 hours–72 hours age. Eight essential and nonessential metals (cadmium, cobalt, copper, iron, manganese, molybdenum, selenium, zinc) detected in more than 80% of samples were tested for associations with atypical neurobehavior indicated by NICU Network Neurobehavioral Scale using logistic regression and in a quantile g-computation analysis to evaluate the joint association between placental metal mixture and neurobehavioral profiles. RESULTS: Individually, a doubling of placental cadmium concentrations was associated with an increased likelihood of being in the atypical neurobehavioral profile (OR = 2.39; 95% CI = 1.05 to 5.71). In the mixture analysis, joint effects of a quartile increase in exposure to all metals was associated with 3-fold increased odds of newborns being assigned to the atypical profile (OR = 3.23; 95% CI = 0.92 to 11.36), with cadmium having the largest weight in the mixture effect. CONCLUSIONS: Prenatal exposure to relatively low levels of a mixture of placental metals was associated with adverse newborn neurobehavior. Examining prenatal metal exposures as a mixture is important for understanding the harmful effects of concomitant exposures in the vulnerable populations.
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spelling pubmed-88355492022-02-14 Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study Tung, Pei Wen Burt, Amber Karagas, Margaret Jackson, Brian P. Punshon, Tracy Lester, Barry Marsit, Carmen J. Environ Epidemiol Original Research Article BACKGROUND: Prenatal exposure to metals can affect the developing fetus and negatively impact neurobehavior. The associations between individual metals and neurodevelopment have been examined, but little work has explored the potentially detrimental neurodevelopmental outcomes associated with the combined impact of coexisting metals. The objective of this study is to evaluate prenatal metal exposure mixtures in the placenta to elucidate the link between their combined effects on newborn neurobehavior. METHOD: This study included 192 infants with available placental metal and NICU Network Neurobehavioral Scale data at 24 hours–72 hours age. Eight essential and nonessential metals (cadmium, cobalt, copper, iron, manganese, molybdenum, selenium, zinc) detected in more than 80% of samples were tested for associations with atypical neurobehavior indicated by NICU Network Neurobehavioral Scale using logistic regression and in a quantile g-computation analysis to evaluate the joint association between placental metal mixture and neurobehavioral profiles. RESULTS: Individually, a doubling of placental cadmium concentrations was associated with an increased likelihood of being in the atypical neurobehavioral profile (OR = 2.39; 95% CI = 1.05 to 5.71). In the mixture analysis, joint effects of a quartile increase in exposure to all metals was associated with 3-fold increased odds of newborns being assigned to the atypical profile (OR = 3.23; 95% CI = 0.92 to 11.36), with cadmium having the largest weight in the mixture effect. CONCLUSIONS: Prenatal exposure to relatively low levels of a mixture of placental metals was associated with adverse newborn neurobehavior. Examining prenatal metal exposures as a mixture is important for understanding the harmful effects of concomitant exposures in the vulnerable populations. Lippincott Williams & Wilkins 2022-01-28 /pmc/articles/PMC8835549/ /pubmed/35169672 http://dx.doi.org/10.1097/EE9.0000000000000194 Text en Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Research Article
Tung, Pei Wen
Burt, Amber
Karagas, Margaret
Jackson, Brian P.
Punshon, Tracy
Lester, Barry
Marsit, Carmen J.
Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study
title Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study
title_full Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study
title_fullStr Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study
title_full_unstemmed Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study
title_short Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study
title_sort prenatal exposure to metal mixtures and newborn neurobehavior in the rhode island child health study
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835549/
https://www.ncbi.nlm.nih.gov/pubmed/35169672
http://dx.doi.org/10.1097/EE9.0000000000000194
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