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Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias
Na(v)1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Na(v)1.5 undergoes strict genomic and non-genomic regulatory and quality control steps...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835759/ https://www.ncbi.nlm.nih.gov/pubmed/35163304 http://dx.doi.org/10.3390/ijms23031381 |
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author | Daimi, Houria Lozano-Velasco, Estefanía Aranega, Amelia Franco, Diego |
author_facet | Daimi, Houria Lozano-Velasco, Estefanía Aranega, Amelia Franco, Diego |
author_sort | Daimi, Houria |
collection | PubMed |
description | Na(v)1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Na(v)1.5 undergoes strict genomic and non-genomic regulatory and quality control steps that allow only newly synthesized channels to reach their final membrane destination and carry out their electrophysiological role. These regulatory pathways are ensured by distinct interacting proteins that accompany the nascent Na(v)1.5 protein along with different subcellular organelles. Defects on a large number of these pathways have a tremendous impact on Na(v)1.5 functionality and are thus intimately linked to cardiac arrhythmias. In the present review, we provide current state-of-the-art information on the molecular events that regulate SCN5A/Na(v)1.5 and the cardiac channelopathies associated with defects in these pathways. |
format | Online Article Text |
id | pubmed-8835759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88357592022-02-12 Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias Daimi, Houria Lozano-Velasco, Estefanía Aranega, Amelia Franco, Diego Int J Mol Sci Review Na(v)1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Na(v)1.5 undergoes strict genomic and non-genomic regulatory and quality control steps that allow only newly synthesized channels to reach their final membrane destination and carry out their electrophysiological role. These regulatory pathways are ensured by distinct interacting proteins that accompany the nascent Na(v)1.5 protein along with different subcellular organelles. Defects on a large number of these pathways have a tremendous impact on Na(v)1.5 functionality and are thus intimately linked to cardiac arrhythmias. In the present review, we provide current state-of-the-art information on the molecular events that regulate SCN5A/Na(v)1.5 and the cardiac channelopathies associated with defects in these pathways. MDPI 2022-01-26 /pmc/articles/PMC8835759/ /pubmed/35163304 http://dx.doi.org/10.3390/ijms23031381 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Daimi, Houria Lozano-Velasco, Estefanía Aranega, Amelia Franco, Diego Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
title | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
title_full | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
title_fullStr | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
title_full_unstemmed | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
title_short | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
title_sort | genomic and non-genomic regulatory mechanisms of the cardiac sodium channel in cardiac arrhythmias |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835759/ https://www.ncbi.nlm.nih.gov/pubmed/35163304 http://dx.doi.org/10.3390/ijms23031381 |
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