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Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias

Na(v)1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Na(v)1.5 undergoes strict genomic and non-genomic regulatory and quality control steps...

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Autores principales: Daimi, Houria, Lozano-Velasco, Estefanía, Aranega, Amelia, Franco, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835759/
https://www.ncbi.nlm.nih.gov/pubmed/35163304
http://dx.doi.org/10.3390/ijms23031381
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author Daimi, Houria
Lozano-Velasco, Estefanía
Aranega, Amelia
Franco, Diego
author_facet Daimi, Houria
Lozano-Velasco, Estefanía
Aranega, Amelia
Franco, Diego
author_sort Daimi, Houria
collection PubMed
description Na(v)1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Na(v)1.5 undergoes strict genomic and non-genomic regulatory and quality control steps that allow only newly synthesized channels to reach their final membrane destination and carry out their electrophysiological role. These regulatory pathways are ensured by distinct interacting proteins that accompany the nascent Na(v)1.5 protein along with different subcellular organelles. Defects on a large number of these pathways have a tremendous impact on Na(v)1.5 functionality and are thus intimately linked to cardiac arrhythmias. In the present review, we provide current state-of-the-art information on the molecular events that regulate SCN5A/Na(v)1.5 and the cardiac channelopathies associated with defects in these pathways.
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spelling pubmed-88357592022-02-12 Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias Daimi, Houria Lozano-Velasco, Estefanía Aranega, Amelia Franco, Diego Int J Mol Sci Review Na(v)1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Na(v)1.5 undergoes strict genomic and non-genomic regulatory and quality control steps that allow only newly synthesized channels to reach their final membrane destination and carry out their electrophysiological role. These regulatory pathways are ensured by distinct interacting proteins that accompany the nascent Na(v)1.5 protein along with different subcellular organelles. Defects on a large number of these pathways have a tremendous impact on Na(v)1.5 functionality and are thus intimately linked to cardiac arrhythmias. In the present review, we provide current state-of-the-art information on the molecular events that regulate SCN5A/Na(v)1.5 and the cardiac channelopathies associated with defects in these pathways. MDPI 2022-01-26 /pmc/articles/PMC8835759/ /pubmed/35163304 http://dx.doi.org/10.3390/ijms23031381 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Daimi, Houria
Lozano-Velasco, Estefanía
Aranega, Amelia
Franco, Diego
Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias
title Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias
title_full Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias
title_fullStr Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias
title_full_unstemmed Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias
title_short Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias
title_sort genomic and non-genomic regulatory mechanisms of the cardiac sodium channel in cardiac arrhythmias
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835759/
https://www.ncbi.nlm.nih.gov/pubmed/35163304
http://dx.doi.org/10.3390/ijms23031381
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