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Epigenetics in the Diagnosis and Therapy of Malignant Melanoma
Epigenetic mechanisms are fundamentally important for cancer initiation and development. However, a survey of the literature reveals that, to date, they appear less comprehensively investigated in melanoma than in many other cancers, e.g., prostate, breast, and colon carcinoma. The aim of this revie...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835790/ https://www.ncbi.nlm.nih.gov/pubmed/35163453 http://dx.doi.org/10.3390/ijms23031531 |
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author | Santourlidis, Simeon Schulz, Wolfgang A. Araúzo-Bravo, Marcos J. Gerovska, Daniela Ott, Pauline Bendhack, Marcelo L. Hassan, Mohamed Erichsen, Lars |
author_facet | Santourlidis, Simeon Schulz, Wolfgang A. Araúzo-Bravo, Marcos J. Gerovska, Daniela Ott, Pauline Bendhack, Marcelo L. Hassan, Mohamed Erichsen, Lars |
author_sort | Santourlidis, Simeon |
collection | PubMed |
description | Epigenetic mechanisms are fundamentally important for cancer initiation and development. However, a survey of the literature reveals that, to date, they appear less comprehensively investigated in melanoma than in many other cancers, e.g., prostate, breast, and colon carcinoma. The aim of this review is to provide a short summary of epigenetic aspects of functional relevance for melanoma pathogenesis. In addition, some new perspectives from epigenetic research in other cancers with potential for melanoma diagnosis and therapy are introduced. For example, the PrimeEpiHit hypothesis in urothelial carcinoma, which, similarly to malignant melanoma, can also be triggered by a single exogenous noxa, states that one of the first steps for cancer initiation could be epigenetic changes in key genes of one-carbon metabolism. The application of such insights may contribute to further progress in the diagnosis and therapy of melanoma, a deadly type of cancer. |
format | Online Article Text |
id | pubmed-8835790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88357902022-02-12 Epigenetics in the Diagnosis and Therapy of Malignant Melanoma Santourlidis, Simeon Schulz, Wolfgang A. Araúzo-Bravo, Marcos J. Gerovska, Daniela Ott, Pauline Bendhack, Marcelo L. Hassan, Mohamed Erichsen, Lars Int J Mol Sci Review Epigenetic mechanisms are fundamentally important for cancer initiation and development. However, a survey of the literature reveals that, to date, they appear less comprehensively investigated in melanoma than in many other cancers, e.g., prostate, breast, and colon carcinoma. The aim of this review is to provide a short summary of epigenetic aspects of functional relevance for melanoma pathogenesis. In addition, some new perspectives from epigenetic research in other cancers with potential for melanoma diagnosis and therapy are introduced. For example, the PrimeEpiHit hypothesis in urothelial carcinoma, which, similarly to malignant melanoma, can also be triggered by a single exogenous noxa, states that one of the first steps for cancer initiation could be epigenetic changes in key genes of one-carbon metabolism. The application of such insights may contribute to further progress in the diagnosis and therapy of melanoma, a deadly type of cancer. MDPI 2022-01-28 /pmc/articles/PMC8835790/ /pubmed/35163453 http://dx.doi.org/10.3390/ijms23031531 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Santourlidis, Simeon Schulz, Wolfgang A. Araúzo-Bravo, Marcos J. Gerovska, Daniela Ott, Pauline Bendhack, Marcelo L. Hassan, Mohamed Erichsen, Lars Epigenetics in the Diagnosis and Therapy of Malignant Melanoma |
title | Epigenetics in the Diagnosis and Therapy of Malignant Melanoma |
title_full | Epigenetics in the Diagnosis and Therapy of Malignant Melanoma |
title_fullStr | Epigenetics in the Diagnosis and Therapy of Malignant Melanoma |
title_full_unstemmed | Epigenetics in the Diagnosis and Therapy of Malignant Melanoma |
title_short | Epigenetics in the Diagnosis and Therapy of Malignant Melanoma |
title_sort | epigenetics in the diagnosis and therapy of malignant melanoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835790/ https://www.ncbi.nlm.nih.gov/pubmed/35163453 http://dx.doi.org/10.3390/ijms23031531 |
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