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Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential
The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in the regulation of cell proliferation, survival, and motility in response to availability of energy and nutrients as well as mitogens. The mTOR signaling axis regulates important biological processes, including...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835793/ https://www.ncbi.nlm.nih.gov/pubmed/35163615 http://dx.doi.org/10.3390/ijms23031693 |
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author | Karagianni, Fani Pavlidis, Antreas Malakou, Lina S. Piperi, Christina Papadavid, Evangelia |
author_facet | Karagianni, Fani Pavlidis, Antreas Malakou, Lina S. Piperi, Christina Papadavid, Evangelia |
author_sort | Karagianni, Fani |
collection | PubMed |
description | The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in the regulation of cell proliferation, survival, and motility in response to availability of energy and nutrients as well as mitogens. The mTOR signaling axis regulates important biological processes, including cellular growth, metabolism, and survival in many tissues. In the skin, dysregulation of PI3K/AKT/mTOR pathway may lead to severe pathological conditions characterized by uncontrolled proliferation and inflammation, including skin hyperproliferative as well as malignant diseases. Herein, we provide an update on the current knowledge regarding the pathogenic implication of the mTOR pathway in skin diseases with inflammatory features (such as psoriasis, atopic dermatitis, pemphigus, and acne) and malignant characteristics (such as cutaneous T cell lymphoma and melanoma) while we critically discuss current and future perspectives for therapeutic targeting of mTOR axis in clinical practice. |
format | Online Article Text |
id | pubmed-8835793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88357932022-02-12 Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential Karagianni, Fani Pavlidis, Antreas Malakou, Lina S. Piperi, Christina Papadavid, Evangelia Int J Mol Sci Review The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in the regulation of cell proliferation, survival, and motility in response to availability of energy and nutrients as well as mitogens. The mTOR signaling axis regulates important biological processes, including cellular growth, metabolism, and survival in many tissues. In the skin, dysregulation of PI3K/AKT/mTOR pathway may lead to severe pathological conditions characterized by uncontrolled proliferation and inflammation, including skin hyperproliferative as well as malignant diseases. Herein, we provide an update on the current knowledge regarding the pathogenic implication of the mTOR pathway in skin diseases with inflammatory features (such as psoriasis, atopic dermatitis, pemphigus, and acne) and malignant characteristics (such as cutaneous T cell lymphoma and melanoma) while we critically discuss current and future perspectives for therapeutic targeting of mTOR axis in clinical practice. MDPI 2022-02-01 /pmc/articles/PMC8835793/ /pubmed/35163615 http://dx.doi.org/10.3390/ijms23031693 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Karagianni, Fani Pavlidis, Antreas Malakou, Lina S. Piperi, Christina Papadavid, Evangelia Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential |
title | Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential |
title_full | Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential |
title_fullStr | Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential |
title_full_unstemmed | Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential |
title_short | Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential |
title_sort | predominant role of mtor signaling in skin diseases with therapeutic potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835793/ https://www.ncbi.nlm.nih.gov/pubmed/35163615 http://dx.doi.org/10.3390/ijms23031693 |
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