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Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review

Neurodegenerative disorders such as Alzheimer’s disease (AD) are distinguished by the irreversible degeneration of central nervous system function and structure. AD is characterized by several different neuropathologies—among others, it interferes with neuropsychiatrical controls and cognitive funct...

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Autores principales: Wojtunik-Kulesza, Karolina, Oniszczuk, Tomasz, Mołdoch, Jarosław, Kowalska, Iwona, Szponar, Jarosław, Oniszczuk, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835836/
https://www.ncbi.nlm.nih.gov/pubmed/35163136
http://dx.doi.org/10.3390/ijms23031212
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author Wojtunik-Kulesza, Karolina
Oniszczuk, Tomasz
Mołdoch, Jarosław
Kowalska, Iwona
Szponar, Jarosław
Oniszczuk, Anna
author_facet Wojtunik-Kulesza, Karolina
Oniszczuk, Tomasz
Mołdoch, Jarosław
Kowalska, Iwona
Szponar, Jarosław
Oniszczuk, Anna
author_sort Wojtunik-Kulesza, Karolina
collection PubMed
description Neurodegenerative disorders such as Alzheimer’s disease (AD) are distinguished by the irreversible degeneration of central nervous system function and structure. AD is characterized by several different neuropathologies—among others, it interferes with neuropsychiatrical controls and cognitive functions. This disease is the number one neurodegenerative disorder; however, its treatment options are few and, unfortunately, ineffective. In the new strategies devised for AD prevention and treatment, the application of plant-based natural products is especially popular due to lesser side effects associated with their taking. Moreover, their neuroprotective activities target different pathological mechanisms. The current review presents the anti-AD properties of several natural plant substances. The paper throws light on products under in vitro and in vivo trials and compiles information on their mechanism of actions. Knowledge of the properties of such plant compounds and their combinations will surely lead to discovering new potent medicines for the treatment of AD with lesser side effects than the currently available pharmacological proceedings.
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spelling pubmed-88358362022-02-12 Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review Wojtunik-Kulesza, Karolina Oniszczuk, Tomasz Mołdoch, Jarosław Kowalska, Iwona Szponar, Jarosław Oniszczuk, Anna Int J Mol Sci Review Neurodegenerative disorders such as Alzheimer’s disease (AD) are distinguished by the irreversible degeneration of central nervous system function and structure. AD is characterized by several different neuropathologies—among others, it interferes with neuropsychiatrical controls and cognitive functions. This disease is the number one neurodegenerative disorder; however, its treatment options are few and, unfortunately, ineffective. In the new strategies devised for AD prevention and treatment, the application of plant-based natural products is especially popular due to lesser side effects associated with their taking. Moreover, their neuroprotective activities target different pathological mechanisms. The current review presents the anti-AD properties of several natural plant substances. The paper throws light on products under in vitro and in vivo trials and compiles information on their mechanism of actions. Knowledge of the properties of such plant compounds and their combinations will surely lead to discovering new potent medicines for the treatment of AD with lesser side effects than the currently available pharmacological proceedings. MDPI 2022-01-21 /pmc/articles/PMC8835836/ /pubmed/35163136 http://dx.doi.org/10.3390/ijms23031212 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wojtunik-Kulesza, Karolina
Oniszczuk, Tomasz
Mołdoch, Jarosław
Kowalska, Iwona
Szponar, Jarosław
Oniszczuk, Anna
Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review
title Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review
title_full Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review
title_fullStr Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review
title_full_unstemmed Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review
title_short Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review
title_sort selected natural products in neuroprotective strategies for alzheimer’s disease—a non-systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835836/
https://www.ncbi.nlm.nih.gov/pubmed/35163136
http://dx.doi.org/10.3390/ijms23031212
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