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Up-Regulation of Cyclooxygenase-2 (COX-2) Expression by Temozolomide (TMZ) in Human Glioblastoma (GBM) Cell Lines

TMZ-resistance remains a main limitation in glioblastoma (GBM) treatment. TMZ is an alkylating agent whose cytotoxicity is modulated by O6-methylguanine-DNA methyltransferase (MGMT), whose expression is determined by MGMT gene promoter methylation status. The inflammatory marker COX-2 has been impli...

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Detalles Bibliográficos
Autores principales:	Lombardi, Francesca, Augello, Francesca Rosaria, Artone, Serena, Gugu, Mitilda Karoli, Cifone, Maria Grazia, Cinque, Benedetta, Palumbo, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835858/ https://www.ncbi.nlm.nih.gov/pubmed/35163465 http://dx.doi.org/10.3390/ijms23031545

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