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Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer
Monocytes and their tissue counterpart macrophages (MP) constitute the front line of the immune system. Indeed, they are able to rapidly and efficiently detect both external and internal danger signals, thereby activating the immune system to eradicate the disturbing biological, chemical, or physica...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835955/ https://www.ncbi.nlm.nih.gov/pubmed/35163420 http://dx.doi.org/10.3390/ijms23031496 |
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author | Degboé, Yannick Poupot, Rémy Poupot, Mary |
author_facet | Degboé, Yannick Poupot, Rémy Poupot, Mary |
author_sort | Degboé, Yannick |
collection | PubMed |
description | Monocytes and their tissue counterpart macrophages (MP) constitute the front line of the immune system. Indeed, they are able to rapidly and efficiently detect both external and internal danger signals, thereby activating the immune system to eradicate the disturbing biological, chemical, or physical agents. They are also in charge of the control of the immune response and account for the repair of the damaged tissues, eventually restoring tissue homeostasis. The balance between these dual activities must be thoroughly controlled in space and time. Any sustained unbalanced response of MP leads to pathological disorders, such as chronic inflammation, or favors cancer development and progression. In this review, we take advantage of our expertise in chronic inflammation, especially in rheumatoid arthritis, and in cancer, to highlight the pivotal role of MP in the physiopathology of these disorders and to emphasize the repolarization of unbalanced MP as a promising therapeutic strategy to control these diseases. |
format | Online Article Text |
id | pubmed-8835955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88359552022-02-12 Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer Degboé, Yannick Poupot, Rémy Poupot, Mary Int J Mol Sci Review Monocytes and their tissue counterpart macrophages (MP) constitute the front line of the immune system. Indeed, they are able to rapidly and efficiently detect both external and internal danger signals, thereby activating the immune system to eradicate the disturbing biological, chemical, or physical agents. They are also in charge of the control of the immune response and account for the repair of the damaged tissues, eventually restoring tissue homeostasis. The balance between these dual activities must be thoroughly controlled in space and time. Any sustained unbalanced response of MP leads to pathological disorders, such as chronic inflammation, or favors cancer development and progression. In this review, we take advantage of our expertise in chronic inflammation, especially in rheumatoid arthritis, and in cancer, to highlight the pivotal role of MP in the physiopathology of these disorders and to emphasize the repolarization of unbalanced MP as a promising therapeutic strategy to control these diseases. MDPI 2022-01-28 /pmc/articles/PMC8835955/ /pubmed/35163420 http://dx.doi.org/10.3390/ijms23031496 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Degboé, Yannick Poupot, Rémy Poupot, Mary Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
title | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
title_full | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
title_fullStr | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
title_full_unstemmed | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
title_short | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
title_sort | repolarization of unbalanced macrophages: unmet medical need in chronic inflammation and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835955/ https://www.ncbi.nlm.nih.gov/pubmed/35163420 http://dx.doi.org/10.3390/ijms23031496 |
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