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Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling
Fetal stress is known to increase susceptibility to cardiometabolic diseases and hypertension in adult age in a process known as fetal programming. This study investigated the relationship between vascular RAS, oxidative damage and remodeling in fetal programming. Six-month old Sprague-Dawley offspr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835999/ https://www.ncbi.nlm.nih.gov/pubmed/35163158 http://dx.doi.org/10.3390/ijms23031233 |
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author | Vieira-Rocha, Maria Sofia Rodriguez-Rodriguez, Pilar Ferreira-Duarte, Mariana Faria, Miguel Sousa, Joana Beatriz Morato, Manuela Arribas, Silvia Magdalena Diniz, Carmen |
author_facet | Vieira-Rocha, Maria Sofia Rodriguez-Rodriguez, Pilar Ferreira-Duarte, Mariana Faria, Miguel Sousa, Joana Beatriz Morato, Manuela Arribas, Silvia Magdalena Diniz, Carmen |
author_sort | Vieira-Rocha, Maria Sofia |
collection | PubMed |
description | Fetal stress is known to increase susceptibility to cardiometabolic diseases and hypertension in adult age in a process known as fetal programming. This study investigated the relationship between vascular RAS, oxidative damage and remodeling in fetal programming. Six-month old Sprague-Dawley offspring from mothers that were fed ad libitum (CONTROL) or with 50% intake during the second half of gestation (maternal undernutrition, MUN) were used. qPCR or immunohistochemistry were used to obtain the expression of receptors and enzymes. Plasma levels of carbonyls were measured by spectrophotometry. In mesenteric arteries from MUN rats we detected an upregulation of ACE, ACE2, AT(1) receptors and NADPH oxidase, and lower expression of AT(2), Mas and MrgD receptors compared to CONTROL. Systolic and diastolic blood pressure and plasma levels of carbonyls were higher in MUN than in CONTROL. Vascular morphology evidenced an increased media/lumen ratio and adventitia/lumen ratio, and more connective tissue in MUN compared to CONTROL. In conclusion, fetal undernutrition indices RAS alterations and oxidative damage which may contribute to the remodeling of mesenteric arteries, and increase the risk of adverse cardiovascular events and hypertension. |
format | Online Article Text |
id | pubmed-8835999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88359992022-02-12 Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling Vieira-Rocha, Maria Sofia Rodriguez-Rodriguez, Pilar Ferreira-Duarte, Mariana Faria, Miguel Sousa, Joana Beatriz Morato, Manuela Arribas, Silvia Magdalena Diniz, Carmen Int J Mol Sci Article Fetal stress is known to increase susceptibility to cardiometabolic diseases and hypertension in adult age in a process known as fetal programming. This study investigated the relationship between vascular RAS, oxidative damage and remodeling in fetal programming. Six-month old Sprague-Dawley offspring from mothers that were fed ad libitum (CONTROL) or with 50% intake during the second half of gestation (maternal undernutrition, MUN) were used. qPCR or immunohistochemistry were used to obtain the expression of receptors and enzymes. Plasma levels of carbonyls were measured by spectrophotometry. In mesenteric arteries from MUN rats we detected an upregulation of ACE, ACE2, AT(1) receptors and NADPH oxidase, and lower expression of AT(2), Mas and MrgD receptors compared to CONTROL. Systolic and diastolic blood pressure and plasma levels of carbonyls were higher in MUN than in CONTROL. Vascular morphology evidenced an increased media/lumen ratio and adventitia/lumen ratio, and more connective tissue in MUN compared to CONTROL. In conclusion, fetal undernutrition indices RAS alterations and oxidative damage which may contribute to the remodeling of mesenteric arteries, and increase the risk of adverse cardiovascular events and hypertension. MDPI 2022-01-22 /pmc/articles/PMC8835999/ /pubmed/35163158 http://dx.doi.org/10.3390/ijms23031233 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vieira-Rocha, Maria Sofia Rodriguez-Rodriguez, Pilar Ferreira-Duarte, Mariana Faria, Miguel Sousa, Joana Beatriz Morato, Manuela Arribas, Silvia Magdalena Diniz, Carmen Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling |
title | Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling |
title_full | Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling |
title_fullStr | Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling |
title_full_unstemmed | Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling |
title_short | Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling |
title_sort | fetal undernutrition modifies vascular ras balance enhancing oxidative damage and contributing to remodeling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835999/ https://www.ncbi.nlm.nih.gov/pubmed/35163158 http://dx.doi.org/10.3390/ijms23031233 |
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