Cargando…

GPR18-Mediated Relaxation of Human Isolated Pulmonary Arteries

GPR18 receptor protein was detected in the heart and vasculature and appears to play a functional role in the cardiovascular system. We investigated the effects of the new GPR18 agonists PSB-MZ-1415 and PSB-MZ-1440 and the new GPR18 antagonist PSB-CB-27 on isolated human pulmonary arteries (hPAs) an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kozłowska, Hanna, Malinowska, Barbara, Baranowska-Kuczko, Marta, Kusaczuk, Magdalena, Nesterowicz, Miłosz, Kozłowski, Mirosław, Müller, Christa E., Kieć-Kononowicz, Katarzyna, Schlicker, Eberhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836012/ https://www.ncbi.nlm.nih.gov/pubmed/35163351 http://dx.doi.org/10.3390/ijms23031427

Ejemplares similares

Relaxation of human pulmonary arteries by PPARγ agonists
por: Kozłowska, Hanna, et al.
Publicado: (2013)

Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries
por: Baranowska-Kuczko, Marta, et al.
Publicado: (2014)

Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities
por: Baranowska-Kuczko, Marta, et al.
Publicado: (2020)

Reduction of the serotonin 5-HT(1B) and 5-HT(2A) receptor-mediated contraction of human pulmonary artery by the combined 5-HT(1B) receptor antagonist and serotonin transporter inhibitor LY393558
por: Baranowska-Kuczko, Marta, et al.
Publicado: (2020)

Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19 †
por: Malinowska, Barbara, et al.
Publicado: (2021)

Vasoprotective Endothelial Effects of Chronic Cannabidiol Treatment and Its Influence on the Endocannabinoid System in Rats with Primary and Secondary Hypertension
por: Baranowska-Kuczko, Marta, et al.
Publicado: (2021)

Cross-Talk between the (Endo)Cannabinoid and Renin-Angiotensin Systems: Basic Evidence and Potential Therapeutic Significance
por: Mińczuk, Krzysztof, et al.
Publicado: (2022)

The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects
por: Kotańska, Magdalena, et al.
Publicado: (2021)

Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating
por: Kotańska, Magdalena, et al.
Publicado: (2021)

Modulation of Cardiovascular Function in Primary Hypertension in Rat by SKA-31, an Activator of K(Ca)2.x and K(Ca)3.1 Channels
por: Kloza, Monika, et al.
Publicado: (2019)

CB(1) receptor activation in the rat paraventricular nucleus induces bi-directional cardiovascular effects via modification of glutamatergic and GABAergic neurotransmission
por: Grzęda, Emilia, et al.
Publicado: (2016)

Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18
por: Neumann, Alexander, et al.
Publicado: (2020)

Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders
por: Frankowska, Małgorzata, et al.
Publicado: (2023)

Structure Prediction, Evaluation, and Validation of GPR18 Lipid Receptor Using Free Programs
por: Michalik, Ilona, et al.
Publicado: (2022)

Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18
por: Flegel, Caroline, et al.
Publicado: (2016)

Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597
por: Baranowska-Kuczko, Marta, et al.
Publicado: (2021)

Cannabinoids—A New Perspective in Adjuvant Therapy for Pulmonary Hypertension
por: Krzyżewska, Anna, et al.
Publicado: (2021)

Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension
por: Krzyżewska, Anna, et al.
Publicado: (2022)

Cannabidiol Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats
por: Sadowska, Olga, et al.
Publicado: (2020)

Weak Hypotensive Effect of Chronic Administration of the Dual FAAH/MAGL Inhibitor JZL195 in Spontaneously Hypertensive Rats as Revealed by Area under the Curve Analysis
por: Toczek, Marek, et al.
Publicado: (2023)

The Stereoselectivity and Hydrolysis Efficiency of Recombinant d-Hydantoinase from Vigna angularis Against 5-Benzylhydantoin Derivatives with Halogen and Methyl Substituents
por: Latacz, Gniewomir, et al.
Publicado: (2014)

Cross-Talk between CB(1), AT(1), AT(2) and Mas Receptors Responsible for Blood Pressure Control in the Paraventricular Nucleus of Hypothalamus in Conscious Spontaneously Hypertensive Rats and Their Normotensive Controls
por: Mińczuk, Krzysztof, et al.
Publicado: (2022)

Polypharmacology: promises and new drugs in 2022
por: Ryszkiewicz, Piotr, et al.
Publicado: (2023)

Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice
por: Kotańska, Magdalena, et al.
Publicado: (2022)

The histamine H(3) receptor inverse agonist pitolisant reduces body weight in obese mice
por: Kotańska, Magdalena, et al.
Publicado: (2018)

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice
por: Bastaki, Salim M, et al.
Publicado: (2018)

Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus
por: Handzlik, Jadwiga, et al.
Publicado: (2013)

Chalcones as Potential Ligands for the Treatment of Parkinson’s Disease
por: Królicka, Ewelina, et al.
Publicado: (2022)

Cannabinoids in arterial, pulmonary and portal hypertension – mechanisms of action and potential therapeutic significance
por: Malinowska, Barbara, et al.
Publicado: (2018)

Evaluation of Some Safety Parameters of Dual Histamine H(3) and Sigma-2 Receptor Ligands with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2023)

Cannabidiol Affects the Bezold-Jarisch Reflex via TRPV1 and 5-HT(3) Receptors and Has Peripheral Sympathomimetic Effects in Spontaneously Hypertensive and Normotensive Rats
por: Kossakowski, Rafał, et al.
Publicado: (2019)

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats
por: Alachkar, Alaa, et al.
Publicado: (2017)

Salsolinol—neurotoxic or Neuroprotective?
por: Kurnik-Łucka, Magdalena, et al.
Publicado: (2019)

The FAAH Inhibitor URB597 Modulates Lipid Mediators in the Brain of Rats with Spontaneous Hypertension
por: Biernacki, Michał, et al.
Publicado: (2020)

Thermal Processes Using Attosecond Laser Pulses: When Time Matters
por: Kozłowski, Mirosław, et al.
Publicado: (2006)

Why Do Marijuana and Synthetic Cannabimimetics Induce Acute Myocardial Infarction in Healthy Young People?
por: Weresa, Jolanta, et al.
Publicado: (2022)

LC–MS–MS Method for the Analysis of New Non-Imidazole Histamine H(3) Receptor Antagonist 1-[3-(4-tert-Butylphenoxy)propyl]piperidine in Rat Serum—Application to Pharmacokinetic Studies
por: Szafarz, Malgorzata, et al.
Publicado: (2011)

A Taxicab geometry quantification system to evaluate the performance of in silico methods: a case study on adenosine receptors ligands
por: Kuder, Kamil J., et al.
Publicado: (2020)

Oxidation, Glycation, and Carbamylation of Salivary Biomolecules in Healthy Children, Adults, and the Elderly: Can Saliva Be Used in the Assessment of Aging?
por: Maciejczyk, Mateusz, et al.
Publicado: (2022)

Discovery of Potential, Dual-Active Histamine H(3) Receptor Ligands with Combined Antioxidant Properties
por: Kuder, Kamil J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8vg2f87cb7h4tok38fva1go5lp