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FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story

The FK506-binding protein 52 (FKBP52) belongs to a large family of ubiquitously expressed and highly conserved proteins (FKBPs) that share an FKBP domain and possess Peptidyl-Prolyl Isomerase (PPIase) activity. PPIase activity catalyzes the isomerization of Peptidyl-Prolyl bonds and therefore influe...

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Autores principales: Chambraud, Béatrice, Byrne, Cillian, Meduri, Geri, Baulieu, Etienne Emile, Giustiniani, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836061/
https://www.ncbi.nlm.nih.gov/pubmed/35163662
http://dx.doi.org/10.3390/ijms23031738
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author Chambraud, Béatrice
Byrne, Cillian
Meduri, Geri
Baulieu, Etienne Emile
Giustiniani, Julien
author_facet Chambraud, Béatrice
Byrne, Cillian
Meduri, Geri
Baulieu, Etienne Emile
Giustiniani, Julien
author_sort Chambraud, Béatrice
collection PubMed
description The FK506-binding protein 52 (FKBP52) belongs to a large family of ubiquitously expressed and highly conserved proteins (FKBPs) that share an FKBP domain and possess Peptidyl-Prolyl Isomerase (PPIase) activity. PPIase activity catalyzes the isomerization of Peptidyl-Prolyl bonds and therefore influences target protein folding and function. FKBP52 is particularly abundant in the nervous system and is partially associated with the microtubule network in different cell types suggesting its implication in microtubule function. Various studies have focused on FKBP52, highlighting its importance in several neuronal microtubule-dependent signaling pathways and its possible implication in neurodegenerative diseases such as tauopathies (i.e., Alzheimer disease) and alpha-synucleinopathies (i.e., Parkinson disease). This review summarizes our current understanding of FKBP52 actions in the microtubule environment, its implication in neuronal signaling and function, its interactions with other members of the FKBPs family and its involvement in neurodegenerative disease.
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spelling pubmed-88360612022-02-12 FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story Chambraud, Béatrice Byrne, Cillian Meduri, Geri Baulieu, Etienne Emile Giustiniani, Julien Int J Mol Sci Review The FK506-binding protein 52 (FKBP52) belongs to a large family of ubiquitously expressed and highly conserved proteins (FKBPs) that share an FKBP domain and possess Peptidyl-Prolyl Isomerase (PPIase) activity. PPIase activity catalyzes the isomerization of Peptidyl-Prolyl bonds and therefore influences target protein folding and function. FKBP52 is particularly abundant in the nervous system and is partially associated with the microtubule network in different cell types suggesting its implication in microtubule function. Various studies have focused on FKBP52, highlighting its importance in several neuronal microtubule-dependent signaling pathways and its possible implication in neurodegenerative diseases such as tauopathies (i.e., Alzheimer disease) and alpha-synucleinopathies (i.e., Parkinson disease). This review summarizes our current understanding of FKBP52 actions in the microtubule environment, its implication in neuronal signaling and function, its interactions with other members of the FKBPs family and its involvement in neurodegenerative disease. MDPI 2022-02-03 /pmc/articles/PMC8836061/ /pubmed/35163662 http://dx.doi.org/10.3390/ijms23031738 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chambraud, Béatrice
Byrne, Cillian
Meduri, Geri
Baulieu, Etienne Emile
Giustiniani, Julien
FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story
title FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story
title_full FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story
title_fullStr FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story
title_full_unstemmed FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story
title_short FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story
title_sort fkbp52 in neuronal signaling and neurodegenerative diseases: a microtubule story
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836061/
https://www.ncbi.nlm.nih.gov/pubmed/35163662
http://dx.doi.org/10.3390/ijms23031738
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