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Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects

This review article was designed to evaluate the existing evidence related to the molecular processes of SARS-CoV-2 infection in the oral cavity. The World Health Organization stated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission is produced by respirato...

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Autores principales: Drozdzik, Agnieszka, Drozdzik, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836070/
https://www.ncbi.nlm.nih.gov/pubmed/35163355
http://dx.doi.org/10.3390/ijms23031431
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author Drozdzik, Agnieszka
Drozdzik, Marek
author_facet Drozdzik, Agnieszka
Drozdzik, Marek
author_sort Drozdzik, Agnieszka
collection PubMed
description This review article was designed to evaluate the existing evidence related to the molecular processes of SARS-CoV-2 infection in the oral cavity. The World Health Organization stated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission is produced by respiratory droplets and aerosols from the oral cavity of infected patients. The oral cavity structures, keratinized and non-keratinized mucosa, and salivary glands’ epithelia express SARS-CoV-2 entry and transmission factors, especially angiotensin converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Replication of the virus in cells leads to local and systemic infection spread, and cellular damage is associated with clinical signs and symptoms of the disease in the oral cavity. Saliva, both the cellular and acellular fractions, holds the virus particles and contributes to COVID-19 transmission. The review also presents information about the factors modifying SARS-CoV-2 infection potential and possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the oral cavity. The PubMed and Scopus databases were used to search for suitable keywords such as: SARS-CoV-2, COVID-19, oral virus infection, saliva, crevicular fluid, salivary gland, tongue, oral mucosa, periodontium, gingiva, dental pulp, ACE2, TMPRSS2, Furin, diagnosis, topical treatment, vaccine and related words in relevant publications up to 28 December 2021. Data extraction and quality evaluation of the articles were performed by two reviewers, and 63 articles were included in the final review.
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spelling pubmed-88360702022-02-12 Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects Drozdzik, Agnieszka Drozdzik, Marek Int J Mol Sci Review This review article was designed to evaluate the existing evidence related to the molecular processes of SARS-CoV-2 infection in the oral cavity. The World Health Organization stated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission is produced by respiratory droplets and aerosols from the oral cavity of infected patients. The oral cavity structures, keratinized and non-keratinized mucosa, and salivary glands’ epithelia express SARS-CoV-2 entry and transmission factors, especially angiotensin converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Replication of the virus in cells leads to local and systemic infection spread, and cellular damage is associated with clinical signs and symptoms of the disease in the oral cavity. Saliva, both the cellular and acellular fractions, holds the virus particles and contributes to COVID-19 transmission. The review also presents information about the factors modifying SARS-CoV-2 infection potential and possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the oral cavity. The PubMed and Scopus databases were used to search for suitable keywords such as: SARS-CoV-2, COVID-19, oral virus infection, saliva, crevicular fluid, salivary gland, tongue, oral mucosa, periodontium, gingiva, dental pulp, ACE2, TMPRSS2, Furin, diagnosis, topical treatment, vaccine and related words in relevant publications up to 28 December 2021. Data extraction and quality evaluation of the articles were performed by two reviewers, and 63 articles were included in the final review. MDPI 2022-01-27 /pmc/articles/PMC8836070/ /pubmed/35163355 http://dx.doi.org/10.3390/ijms23031431 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Drozdzik, Agnieszka
Drozdzik, Marek
Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects
title Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects
title_full Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects
title_fullStr Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects
title_full_unstemmed Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects
title_short Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects
title_sort oral pathology in covid-19 and sars-cov-2 infection—molecular aspects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836070/
https://www.ncbi.nlm.nih.gov/pubmed/35163355
http://dx.doi.org/10.3390/ijms23031431
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AT drozdzikmarek oralpathologyincovid19andsarscov2infectionmolecularaspects